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Brief Title: A Study of Brentuximab Vedotin and CHP in Frontline Treatment of PTCL With Less Than 10% CD30 Expression
Official Title: A Dual-cohort, Open-label, Phase 2 Study of Brentuximab Vedotin and CHP (A+CHP) in the Frontline Treatment of Subjects With Peripheral T-cell Lymphoma (PTCL) With Less Than 10% CD30 Expression
Study ID: NCT04569032
Brief Summary: This clinical trial will study brentuximab vedotin with CHP to find out if the drugs work for people who have certain types of peripheral T-cell lymphoma (PTCL). It will also find out what side effects occur when brentuximab vedotin and CHP are used together. A side effect is anything the drugs do besides treating cancer. CHP is a type of chemotherapy that uses three drugs (cyclophosphamide, doxorubicin, and prednisone). CHP is approved by the FDA to treat certain types of PTCL.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
University of Alabama at Birmingham, Birmingham, Alabama, United States
Stanford Cancer Center / Blood and Marrow Transplant Program, Stanford, California, United States
Rocky Mountain Cancer Centers - Aurora, Aurora, Colorado, United States
Johns Hopkins Medical Center, Washington, District of Columbia, United States
Illinois Cancer Specialists, Niles, Illinois, United States
Tulane University Hospital and Clinic, New Orleans, Louisiana, United States
Ochsner Medical Center, New Orleans, Louisiana, United States
University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, United States
Memorial Sloan Kettering Cancer Center, New York, New York, United States
Cleveland Clinic, The, Cleveland, Ohio, United States
Oncology Hematology Care, Fairfield, Ohio, United States
University of Tennessee, Knoxville, Tennessee, United States
Texas Oncology - Amarillo, Amarillo, Texas, United States
Texas Oncology - Austin Midtown, Austin, Texas, United States
Texas Oncology - Fort Worth 12th Avenue, Fort Worth, Texas, United States
MD Anderson Cancer Center / University of Texas, Houston, Texas, United States
Texas Oncology - Northeast Texas, Longview, Texas, United States
Virginia Commonwealth University Medical Center, Richmond, Virginia, United States
Virginia Oncology Associates - Virginia Beach, Virginia Beach, Virginia, United States
Fakultni Nemocnice Ostrava, Ostrava - Poruba, Other, Czechia
Fakultni Nemocnice Kralovske Vinohrady, Praha 10, Other, Czechia
Vseobecna fakultni nemocnice v Praze, Praha 2, Other, Czechia
CHD Vendee, Site de La Roche-sur-Yon, Les Oudairies, Cedex 9, Other, France
Centre Hospitalier Universitaire de Grenoble, La Tronche, Other, France
Hopital Emile Muller, Mulhouse, Other, France
Groupe Hospitalier du Haut Leveque, Pessac, Other, France
Centre Hospitalier Lyon Sud, Pierre Benite Cedex, Other, France
Centre Henri Becquerel / Centre Regional de Lutte Contre le Cancer, Rouen, Other, France
Azienda Ospedaliero-Universitaria di Bologna Policlinico S. Orsola-Malpighi, Bologna, Other, Italy
Azienda Ospedaliera Spedali Civili di Brescia, Brescia, Other, Italy
Candiolo Cancer Institute, FPO-IRCCS, Candiolo (Torino), Other, Italy
A.O.U Policlinico G. Rodolico S. Marco, Catania, Other, Italy
Azienda Ospedaliera Universitaria San Martino, Genova, Other, Italy
IRCSS Policlinico San Matteo, Pavia, Other, Italy
Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Other, Italy
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, , Italy
Hospital de la Santa Creu i Sant Paul, Barcelona, Other, Spain
L'Institut Catala d'Oncologia, L'Hospitalet de Llobregat, Other, Spain
MD Anderson Cancer Center - Madrid, Madrid, Other, Spain
Hospital Universitario 12 de Octubre, Madrid, Other, Spain
Hospital Universitario La Paz, Madrid, Other, Spain
Hospital Costa del Sol, Marbella, Other, Spain
Hospital Clinico Universitario de Salamanca, Salamanca, Other, Spain
Hospital Universitario Virgen del Rocio, Sevilla, Other, Spain
The Beatson West of Scotland Cancer Centre, Glasgow, Other, United Kingdom
Oxford University Hospitals, Headington, Other, United Kingdom
University College London Hospitals NHS Foundation Trust, London, Other, United Kingdom
The Royal Marsden Hospital, London, Other, United Kingdom
Imperial College Healthcare NHS Trust, London, Other, United Kingdom
Christie Hospital NHS Foundation Trust, Manchester, Other, United Kingdom
The Royal Marsden Hospital (Surrey), Sutton, Other, United Kingdom
Name: Robert Sims, MD
Affiliation: Seagen Inc.
Role: STUDY_DIRECTOR