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Spots Global Cancer Trial Database for A Study of Brentuximab Vedotin and CHP in Frontline Treatment of PTCL With Less Than 10% CD30 Expression

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Trial Identification

Brief Title: A Study of Brentuximab Vedotin and CHP in Frontline Treatment of PTCL With Less Than 10% CD30 Expression

Official Title: A Dual-cohort, Open-label, Phase 2 Study of Brentuximab Vedotin and CHP (A+CHP) in the Frontline Treatment of Subjects With Peripheral T-cell Lymphoma (PTCL) With Less Than 10% CD30 Expression

Study ID: NCT04569032

Study Description

Brief Summary: This clinical trial will study brentuximab vedotin with CHP to find out if the drugs work for people who have certain types of peripheral T-cell lymphoma (PTCL). It will also find out what side effects occur when brentuximab vedotin and CHP are used together. A side effect is anything the drugs do besides treating cancer. CHP is a type of chemotherapy that uses three drugs (cyclophosphamide, doxorubicin, and prednisone). CHP is approved by the FDA to treat certain types of PTCL.

Detailed Description:

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

University of Alabama at Birmingham, Birmingham, Alabama, United States

Stanford Cancer Center / Blood and Marrow Transplant Program, Stanford, California, United States

Rocky Mountain Cancer Centers - Aurora, Aurora, Colorado, United States

Johns Hopkins Medical Center, Washington, District of Columbia, United States

Illinois Cancer Specialists, Niles, Illinois, United States

Tulane University Hospital and Clinic, New Orleans, Louisiana, United States

Ochsner Medical Center, New Orleans, Louisiana, United States

University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, United States

Memorial Sloan Kettering Cancer Center, New York, New York, United States

Cleveland Clinic, The, Cleveland, Ohio, United States

Oncology Hematology Care, Fairfield, Ohio, United States

University of Tennessee, Knoxville, Tennessee, United States

Texas Oncology - Amarillo, Amarillo, Texas, United States

Texas Oncology - Austin Midtown, Austin, Texas, United States

Texas Oncology - Fort Worth 12th Avenue, Fort Worth, Texas, United States

MD Anderson Cancer Center / University of Texas, Houston, Texas, United States

Texas Oncology - Northeast Texas, Longview, Texas, United States

Virginia Commonwealth University Medical Center, Richmond, Virginia, United States

Virginia Oncology Associates - Virginia Beach, Virginia Beach, Virginia, United States

Fakultni Nemocnice Ostrava, Ostrava - Poruba, Other, Czechia

Fakultni Nemocnice Kralovske Vinohrady, Praha 10, Other, Czechia

Vseobecna fakultni nemocnice v Praze, Praha 2, Other, Czechia

CHD Vendee, Site de La Roche-sur-Yon, Les Oudairies, Cedex 9, Other, France

Centre Hospitalier Universitaire de Grenoble, La Tronche, Other, France

Hopital Emile Muller, Mulhouse, Other, France

Groupe Hospitalier du Haut Leveque, Pessac, Other, France

Centre Hospitalier Lyon Sud, Pierre Benite Cedex, Other, France

Centre Henri Becquerel / Centre Regional de Lutte Contre le Cancer, Rouen, Other, France

Azienda Ospedaliero-Universitaria di Bologna Policlinico S. Orsola-Malpighi, Bologna, Other, Italy

Azienda Ospedaliera Spedali Civili di Brescia, Brescia, Other, Italy

Candiolo Cancer Institute, FPO-IRCCS, Candiolo (Torino), Other, Italy

A.O.U Policlinico G. Rodolico S. Marco, Catania, Other, Italy

Azienda Ospedaliera Universitaria San Martino, Genova, Other, Italy

IRCSS Policlinico San Matteo, Pavia, Other, Italy

Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Other, Italy

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, , Italy

Hospital de la Santa Creu i Sant Paul, Barcelona, Other, Spain

L'Institut Catala d'Oncologia, L'Hospitalet de Llobregat, Other, Spain

MD Anderson Cancer Center - Madrid, Madrid, Other, Spain

Hospital Universitario 12 de Octubre, Madrid, Other, Spain

Hospital Universitario La Paz, Madrid, Other, Spain

Hospital Costa del Sol, Marbella, Other, Spain

Hospital Clinico Universitario de Salamanca, Salamanca, Other, Spain

Hospital Universitario Virgen del Rocio, Sevilla, Other, Spain

The Beatson West of Scotland Cancer Centre, Glasgow, Other, United Kingdom

Oxford University Hospitals, Headington, Other, United Kingdom

University College London Hospitals NHS Foundation Trust, London, Other, United Kingdom

The Royal Marsden Hospital, London, Other, United Kingdom

Imperial College Healthcare NHS Trust, London, Other, United Kingdom

Christie Hospital NHS Foundation Trust, Manchester, Other, United Kingdom

The Royal Marsden Hospital (Surrey), Sutton, Other, United Kingdom

Contact Details

Name: Robert Sims, MD

Affiliation: Seagen Inc.

Role: STUDY_DIRECTOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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