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Spots Global Cancer Trial Database for Assessment of Histologic Prognostic Factors in Peritoneal Malignant Mesothelioma

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Trial Identification

Brief Title: Assessment of Histologic Prognostic Factors in Peritoneal Malignant Mesothelioma

Official Title: Assessment of Histologic Prognostic Factors in Peritoneal Malignant Mesothelioma

Study ID: NCT05193006

Interventions

No intervention

Study Description

Brief Summary: Malignant peritoneal mesothelioma is a rare neoplasm. The most common type, the epithelioid type, has been further divided into histological patterns of tubulo-papillary, acinar, adenomatoid, micropapillary, or solid. Its prognosis is improved by the use of a locoregional treatment combining extensive cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC), which increases survival up to 50 months. Histology is one of the most important prognostic variable that, forms the basis for treatment decisions. However, the prognostic of the epithelioid type varies greatly due to its tumor heterogeneity. It is therefore necessary to find prognostic factors of malignant epithelioid peritoneal mesothelioma in order to better define the therapeutic strategy. Among histological factors, solid growth, tumor necrosis, nuclear atypia, and mitotic count were found to be independent prognostic factors in epithelioid malignant pleural mesothelioma. However, in epithelioid malignant peritoneal mesothelioma (EMPM), these factors were studied in small and heterogeneous series in terms of histological growth and definitions used for histological factors. The present large study was conducted to investigate the prognostic impact of several histologic factors in EMPM. Their prognosis impacts were assessed using overall survival (OS) and progression-free survival (PFS) in EMPM.

Detailed Description:

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

UZ Gent, Gent, , Belgium

University Hospital of Lyon, Pierre-Bénite, , France

Institut f. Pathologie und Neuropathologie, Tübingen, , Germany

Zydus Hospitals, Ahmedabad, , India

The Norwegian Radium Hospital, Oslo, , Norway

Fundação Champalimaud, Lisboa, , Portugal

Contact Details

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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