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Brief Title: Pulsatile Gonadotropin-releasing Hormone for Infertility in Non-obese Patients With Polycystic Ovary Syndrome
Official Title: Pulsatile Gonadotropin-releasing Hormone for Infertility in Non-obese Patients With Polycystic Ovary Syndrome
Study ID: NCT03989024
Brief Summary: Polycystic ovary syndrome (PCOS) patients are often accompanied by infertility. Non-obese PCOS infertility is more difficult to treat than obese PCOS. The study included non-obese PCOS patients who had not recovered from regular menstruation after six months of metformin treatment. Half of the patients were treated with clomiphene for ovulation induction and half with GnRH pulse therapy.
Detailed Description: To investigate whether GnRH pulse therapy of non-obese PCOS women can improve ovulation rate.The investigators plan to recruit non-obese PCOS women with abnormal GnRH pulse mode not effective of metformin treatment at childbearing age. By using GnRH pulse therapy and Clomiphene therapy. the investigators will intervent the participants for 3 months and to compare outcome in each group.
Minimum Age: 24 Years
Eligible Ages: ADULT
Sex: FEMALE
Healthy Volunteers: No
Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, , China
Name: TAO TAO, DM
Affiliation: RenJi Hospital
Role: PRINCIPAL_INVESTIGATOR