Spots Global Cancer Trial Database for Compromised Microcirculation in Women With Polycystic Ovary Syndrome

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Trial Identification

Brief Title: Compromised Microcirculation in Women With Polycystic Ovary Syndrome

Official Title: Compromised Microcirculation in Women With Polycystic Ovary Syndrome

Study ID: NCT00757185

Conditions

Polycystic Ovary Syndrome

Interventions

ganirelix acetate

methyl testosterone

Study Description

Brief Summary: The scientific aims of the study are to determine how peripheral microcirculatory responsiveness is altered in obese women with Polycystic Ovary Syndrome (PCOS) during local heating and to determine the mechanism for testosterone effects on peripheral microcirculatory responsiveness in women with PCOS.

Detailed Description: In these studies, we propose to use the skin as a relatively non-invasive model to examine cardiovascular and endothelial function in obese women with and without PCOS. Data have indicated an important role for testosterone in influencing the peripheral microcirculation. While testosterone can lead to vasodilation in the peripheral microcirculation in both men and in women without PCOS, testosterone appears to induce vasoconstriction in women with PCOS. The differential response between women with and without PCOS, and between men and women may be the result of differential ET-1 actions in the vessel, and regulated by the receptor subtype is involved in these actions.