Spots Global Cancer Trial Database for Vitamin D Increases Serum Levels of the Soluble Receptor for Advanced Glycation End Products in Women With PCOS
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Trial Identification
Brief Title: Vitamin D Increases Serum Levels of the Soluble Receptor for Advanced Glycation End Products in Women With PCOS
Official Title: Vitamin D Increases Serum Levels of the Soluble Receptor for Advanced Glycation End Products in Women With PCOS
Study ID: NCT03644212
Interventions
Study Description
Brief Summary: The purpose of this study is to investigate the mechanism that explain the beneficial clinical effect of vitamin D treatment in women with PCOS.
Detailed Description: Seventy-nine women with (n=22) or without (control; n=57) PCOS who were diagnosed with vitamin D deficiency were enrolled. Sixty-three women were treated with oral vit D3 for 8 weeks (16 with PCOS and 47 controls) and 16 women were not treated (6 with PCOS and 10 controls). Serum 25 hydroxy-vitamin D (25 OH-D), sRAGE, and AMH concentrations were measured at baseline and after vit D3 supplementation in the treated group, and 8 weeks apart in the non-treated group. Paired t-test, Wilcoxon signed-rank test, and Pearson correlation were used as appropriate. Main outcome measure: Changes in AMH concentrations following vit D3 replacement.
Eligibility
Minimum Age: 16 Years
Eligible Ages: CHILD, ADULT
Sex: FEMALE
Healthy Volunteers: Yes
Locations
Maimonides Medical Center, OBGYN clinic, Brooklyn, New York, United States
Contact Details
Name: Mohamad Irani, MD
Affiliation: Maimonides Medical Center, Brooklyn, NY, USA
Role: STUDY_DIRECTOR
Name: Zaher Merhi, MD
Affiliation: University of Vermont College of Medicine, Burlington, VT, USA
Role: PRINCIPAL_INVESTIGATOR
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