Spots Global Cancer Trial Database for Secondary Cancers in Myeloproliferative Neoplasms (MPN-K Study)
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Trial Identification
Brief Title: Secondary Cancers in Myeloproliferative Neoplasms (MPN-K Study)
Official Title: Secondary Cancers in Myeloproliferative Neoplasms (MPN-K Study)
Study ID: NCT03745378
Interventions
Study Description
Brief Summary: The incidence of secondary cancer (SC) in patients with myeloproliferative neoplasms (MPN) is high and comparable to that of thrombosis. However, the identification of patient subgroups that might be at increased susceptibility of developing SC has not been systematically addressed. This international case-control study (MPN-K) is aimed to elucidate the prognostic role of JAK2V617F mutation in predicting the occurrence of SC in patients with classical MPN, polycythemia vera (PV), essential thrombocythemia (ET) and myelofibrosis (MF)
Detailed Description: For each recruited case with concomitant diagnosis of myeloproliferative neoplasms (MPN) and secondary cancer each participating center will provide up 3 control patients (1 control for each case could be accepted but the optimal number is 3). Controls are patients with myeloproliferative neoplasms and no history of cancer. Each control will be matched to the paired case for sex, age (+/- 3 years), date of MPN diagnosis (+/- 5 years), and MPN disease duration (+/- 3 years). Each control is censored at the date of the secondary cancer occurrence in his matched case (index date). Data will be collected retrospectively from pre-existing medical records and reported by each center on a web-based and validated eCRF developed to record y all study data. In order to maintain patient privacy, all data records will be treated anonymously and no personal data to identify patient will be recorded: patients will be identified in the study by an alphanumeric code.
Eligibility
Minimum Age:
Eligible Ages: CHILD, ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Palacky University and University Hospital Olomouc, Faculty of Medecine, Olomouc, , Czechia
University Hospital RWTH - Department Oncology, Hematology, Hemostaeseology and stem cell transplantation, Aachen, , Germany
Johannes Wesling Academic Medical Center, Minden, , Germany
Meir Medical Center, Kfar Saba, , Israel
Azienda Sanitaria di Asti - A.S.L. AT Ospedale Cardinal Massaia - S.C. Oncologia, Asti, , Italy
ASST- Papa Giovanni XXIII - UOC Ematologia, Bergamo, , Italy
Ospedale S. Orsola - Malpighi - UO Ematologia, Bologna, , Italy
U.O. Emostasi "G. Rodolico" Dipartimento di Scienze Mediche, Chirurgiche e Tecnologiche Avanzate "G.F. Ingrassia" Università degli Studi di Catania, Catania, , Italy
Azienda Ospedaliera S. Croce e Carle di Cuneo- Divisione di Ematologia,, Cuneo, , Italy
AOU Careggi di Firenze CRIMM- Center of Research and Innovation of Myeloproliferative Neoplasms - Department of Experimental and Clinical Medicine, University of Florence, Firenze, , Italy
Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico - UOC Ematologia, Milano, , Italy
IRCCS Ospedale San Raffaele Unità Operativa di Ematologia e Trapianto Midollo Osseo, Milano, , Italy
ASST MONZA Ospedale San Gerardo Clinica Ematologica, Monza, , Italy
Azienda Ospedaliera Universitaria Federico II di Napoli Divisione di Ematologia e Trapianti del Midollo, Napoli, , Italy
Azienda Ospedaliero Universitaria Maggiore della Carità di Novara SCDU Ematologia, Novara, , Italy
Fondazione IRCCS Policlinico San Matteo S.C Ematologia, Pavia, , Italy
AUSL IRCCS di Reggio Emilia Presidio Osp. Arcispedale Santa Maria Nuova - Unità Ematologia, Reggio Emilia, , Italy
Fondazione Policlinico Universitario A. Gemelli IRCCS UCSC Ematologia, Roma, , Italy
A.O.U. Città della Salute e della Scienza di Torino - Ospedale Molinette- S.C. Ematologia, Torino, , Italy
A.O.U. Città della Salute e della Scienza di Torino Ospedale Molinette - S.C. Ematologia U, Torino, , Italy
Ospedale Borgo Roma - Unità di Ematologia, Verona, , Italy
Ospedale San Bortolo di Vicenza - U.O.C di Ematologia, Vicenza, , Italy
Hospital Clinic, Hematology Department, Barcellona, , Spain
Hospital del Mar - Haematologia Clinica, Barcelona, , Spain
Hospital Universitario Vall d' Hebron - Unit Hematology, Barcelona, , Spain
University Clinical Hospital of Santiago De Campostela - Service of Hematology, Santiago De Compostela, , Spain
Hospita Clinico Universitario - Hematology Department, Valencia, , Spain
Miguel Servet University Hospital, Zaragoza, , Spain
Belfast Health and Social Care Trust - Unit Haematology, Belfast, , United Kingdom
Guy's and St Thomas' NHS Foundation Trust, London, , United Kingdom
Contact Details
Name: Tiziano Barbui, Prof
Affiliation: FROM- Fondazione per la Ricerca Ospedale di Bergamo- ETS
Role: STUDY_CHAIR
Name: Guido Finazzi, Dr
Affiliation: ASST-Papa Giovanni XXIII
Role: PRINCIPAL_INVESTIGATOR
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