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Spots Global Cancer Trial Database for Nutrition and Body Composition in Acute Lymphoblastic Leukemia

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Trial Identification

Brief Title: Nutrition and Body Composition in Acute Lymphoblastic Leukemia

Official Title: Nutrition and Body Composition in Acute Lymphoblastic Leukemia (Environment and Microenvironment in ALL #2)

Study ID: NCT01317940

Study Description

Brief Summary: Many adolescents with acute lymphoblastic leukemia (ALL) have been found to have low bone density by the end of treatment. This can lead to long-term suffering in survivors due to poor bone health. Vitamin D is known to be associated with bone health and previous research has established that Vitamin D insufficiency is very common at diagnosis of ALL and worsens over the course of treatment. Researchers have also learned that a relationship exists between both Vitamin D and fat tissue and ALL and fat tissue. In adolescents being treated for ALL as well as in early survivors, this randomized study will therefore examine the effect of Vitamin D and calcium supplementation on correcting Vitamin D insufficiency and on improving bone density in the context of changes in body composition and body fat. Bone density will be measured by a radiology exam called qCT (quantitative computed tomography) while body composition and body fat will be measured by a different radiology exam called a DXA (dual energy x-ray absorptiometry scan) . The study will also examine in depth the relationship between these three elements - Vitamin D insufficiency, obesity, and ALL - and their impact on bone density.

Detailed Description:

Eligibility

Minimum Age: 10 Years

Eligible Ages: CHILD, ADULT

Sex: ALL

Healthy Volunteers: Yes

Locations

Children's Hospital Los Angeles, Los Angeles, California, United States

Contact Details

Name: Etan Orgel, MD

Affiliation: Children's Hospital Los Angeles

Role: PRINCIPAL_INVESTIGATOR

Name: Steven Mittelman, MD, PhD

Affiliation: Children's Hospital Los Angeles

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

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