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Brief Title: Ovarian Reserve in Premenopausal Breast Cancer
Official Title: A Study to Determine Alteration of Hormone Levels in Premenopausal Patients Receiving Adjuvant or Neo-adjuvant Chemotherapy for Breast Cancer
Study ID: NCT01726322
Brief Summary: This is a translational, mutlicentre study. The aim of this study is to determine whether pre-treatment levels of hormones predict ovarian follicular reserve post adjuvant or neoadjuvant chemotherapy for breast cancer and chemotherapy induced amenorrhea.
Detailed Description: It is proposed that levels of AMH and inhibin A and B measured will give an indication of the residual ovarian reserve in women with breast cancer treated with chemotherapy. In addition, AMH might give an indication of the possible efficacy of GNRH agonists in fertility preservation and the effect on ovarian follicular reserve using different adjuvant chemotherapy regimens. Those likely to be offered GNRH agonists are younger women with no children and a wish to have some in the future. Older women who have completed their families are less likely to be offered a GNRH agonist.
Minimum Age: 18 Years
Eligible Ages: ADULT
Sex: FEMALE
Healthy Volunteers: No
Beacon Hospital, Dublin, Dublin 18, Ireland
Our Lady of Lourdes Hospital, Drogheda, Louth, Ireland
Bon Secours Hospital, Cork, , Ireland
Cork University Hospital, Cork, , Ireland
Beaumont Hospital, Dublin, , Ireland
St James Hospital, Dublin, , Ireland
St Vincent's University Hospital, Dublin, , Ireland
Tallaght University Hospital, Dublin, , Ireland
Sligo General Hospital, Sligo, , Ireland
Waterford Regional Hospital, Waterford, , Ireland