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Brief Title: Ph II Trial of Carboplatin and Pemetrexed With or Without AZD1775 for Untreated Lung Cancer
Official Title: A Phase II Study of AZD1775 Plus Pemetrexed and Carboplatin Followed by a Randomised Comparison of Pemetrexed and Carboplatin With or Without AZD1775 in Patients With Previously Untreated Stage IV Non-Squamous Non-Small-Cell Lung Cancer
Study ID: NCT02087241
Brief Summary: The aim of this study is to combine AZD1775 with standard front-line chemotherapy in subjects with advanced NSCLC.
Detailed Description: This is a randomised, phase II trial comparing AZD1775 plus pemetrexed and carboplatin followed by maintenance AZD1775 and pemetrexed versus pemetrexed and carboplatin followed by maintenance pemetrexed in patients with previously untreated metastatic non-squamous NSCLC with TP53 mutations. The primary endpoint of the trial is assessment of progression-free survival (PFS).
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Research Site, Englewood, Colorado, United States
Research Site, Fort Myers, Florida, United States
Research Site, Orlando, Florida, United States
Research Site, Peoria, Illinois, United States
Research Site, Fort Wayne, Indiana, United States
Research Site, Wichita, Kansas, United States
Research Site, Cincinnati, Ohio, United States
Research Site, Nashville, Tennessee, United States
Name: David R Spigel, MD
Affiliation: SCRI Development Innovations, LLC
Role: PRINCIPAL_INVESTIGATOR