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Spots Global Cancer Trial Database for Ph II Trial of Carboplatin and Pemetrexed With or Without AZD1775 for Untreated Lung Cancer

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Trial Identification

Brief Title: Ph II Trial of Carboplatin and Pemetrexed With or Without AZD1775 for Untreated Lung Cancer

Official Title: A Phase II Study of AZD1775 Plus Pemetrexed and Carboplatin Followed by a Randomised Comparison of Pemetrexed and Carboplatin With or Without AZD1775 in Patients With Previously Untreated Stage IV Non-Squamous Non-Small-Cell Lung Cancer

Study ID: NCT02087241

Study Description

Brief Summary: The aim of this study is to combine AZD1775 with standard front-line chemotherapy in subjects with advanced NSCLC.

Detailed Description: This is a randomised, phase II trial comparing AZD1775 plus pemetrexed and carboplatin followed by maintenance AZD1775 and pemetrexed versus pemetrexed and carboplatin followed by maintenance pemetrexed in patients with previously untreated metastatic non-squamous NSCLC with TP53 mutations. The primary endpoint of the trial is assessment of progression-free survival (PFS).

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Research Site, Englewood, Colorado, United States

Research Site, Fort Myers, Florida, United States

Research Site, Orlando, Florida, United States

Research Site, Peoria, Illinois, United States

Research Site, Fort Wayne, Indiana, United States

Research Site, Wichita, Kansas, United States

Research Site, Cincinnati, Ohio, United States

Research Site, Nashville, Tennessee, United States

Contact Details

Name: David R Spigel, MD

Affiliation: SCRI Development Innovations, LLC

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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