The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.
Brief Title: Primary Cardiac Lymphoma: Italian Multicenter Experience
Official Title: Primary Cardiac Lymphoma: Italian Multicenter Experience
Study ID: NCT05819528
Brief Summary: The rationale of this study is to provide an overview on PCL (Primary Cardiac Lymphoma) in Italy, trying to shed light on unknown aspects of the disease and on unanswered questions about its management that could be helpful in clinical practice.
Detailed Description: Primary cardiac lymphoma (PCL), an extranodal lymphoma involving only the heart (with possible involvement of the pericardium) is a rare entity, accounting for 2% of primary cardiac tumors and 0.5% of extranodal lymphomas. It is more frequent in males; clinical presentation is predominated by cardiac symptoms. The most common histology is Diffuse Large B Cell Lymphoma (DLBCL). Being DLBCL the most frequent histology, patients are usually treated with R-CHOP (rituximab - cyclophosphamide, doxorubicin, vincristine and prednisone) or R-CHOP-like chemoimmunotherapy regimens, with an historically poor outcome, although in the last years survival rates significantly increased. Due to the rarity of this condition, isolated case reports and a few reviews have been published so far, that in most cases included a population collected in a wide period of time, heterogeneously managed both in terms of treatments received and follow-up, and who often did not strictly respect the criteria of PCL. Indeed, while some aspects of PCL are well-known, especially the ones concerning its clinical presentation, a few topics deserve more in-depth analysis. The rationale of this study is to provide an overview on PCL in Italy, trying to shed light on unknown aspects of the disease and on unanswered questions about its management that could be helpful in clinical practice.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Presidio ospedaliero "A. TORTORA" - U.O. Onco-ematologia, Pagani, Salerno, Italy
AOU di Sassari - Ematologia, Sassari, SS, Italy
Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI) - SC Ematologia, Trieste, TS, Italy
Ospedale Dell'angelo - U.O. Ematologia, Mestre, Venezia, Italy
Azienda Ospedaliera Papa Giovanni XXIII - Ematologia, Bergamo, , Italy
ASST Spedali Civili di Brescia - Ematologia, Brescia, , Italy
Azienda Ospedaliero-Universitaria di Ferrara - Arcispedale Sant'Anna - Ematologia e fisiopatologia della coagulazione, Ferrara, , Italy
Istituto Scientifico San Raffaele - Unitа Linfomi - Dipartimento Oncoematologia, Milano, , Italy
Fondazione IRCCS Istituto Nazionale dei Tumori di Milano - Ematologia, Milano, , Italy
ASST Grande Ospedale Metropolitano Niguarda - SC Ematologia, Milano, , Italy
Ospedale S. Maria della Misericordia - Ematologia, Perugia, , Italy
P.O. Spirito Santo di Pescara - UOS Dipartimentale - Centro di diagnosi e Terapia dei linfomi, Pescara, , Italy
AOU Pisana - U.O. Ematologia, Pisa, , Italy
Roma - Universitа Cattolica S. Cuore - Ematologia, Roma, , Italy
AO Sant'Andrea - Ematologia, Roma, , Italy
A.O. S. Maria di Terni - S.C. Oncoematologia, Terni, , Italy
A.O.U. Città della Salute e della Scienza di Torino - Ematologia Universitaria, Torino, , Italy
Ospedale Ca Foncello - S.C di Ematologia, Treviso, , Italy
AOU Integrata di Verona - U.O. Ematologia, Verona, , Italy
Name: Elisa Lucchini, MD
Affiliation: Trieste - Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI) - SC Ematologia
Role: PRINCIPAL_INVESTIGATOR