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Brief Title: Asian Phase II Study of INC424 in Patients With Primary Myelofibrosis (MF), Post-PV MF or Post-ET MF
Official Title: A Multi-national Open-label Phase II Study of the JAK Inhibitor INC424 in Patients With Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis or Post-essential Thrombocythemia Myelofibrosis
Study ID: NCT01392443
Brief Summary: The objective of this study was to determine the efficacy of INC424 as assessed by reduction in spleen volume in patients with primary myelofibrosis (MF), post-polycythemia vera (PV) MF, or post-essential thrombocythemia (ET) MF. The safety and tolerability of INC424 and the effects of INC424 on patient reported outcomes and the duration of response as assessed by reduction in spleen volume was also assessed.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Novartis Investigative Site, Beijing, Beijing, China
Novartis Investigative Site, Guangzhou, Guangdong, China
Novartis Investigative Site, Wuhan, Hubei, China
Novartis Investigative Site, Nanjing, Jiangsu, China
Novartis Investigative Site, Suzhou, Jiangsu, China
Novartis Investigative Site, Chengdu, Sichuan, China
Novartis Investigative Site, Tianjin, Tianjin, China
Novartis Investigative Site, Hangzhou, Zhejiang, China
Novartis Investigative Site, Jinan, , China
Novartis Investigative Site, Shanghai, , China
Novartis Investigative Site, Nagoya, Aichi, Japan
Novartis Investigative Site, Fukuoka city, Fukuoka, Japan
Novartis Investigative Site, Maebashi city, Gunma, Japan
Novartis Investigative Site, Kanazawa-city, Ishikawa, Japan
Novartis Investigative Site, Tsu-city, Mie, Japan
Novartis Investigative Site, Suita city, Osaka, Japan
Novartis Investigative Site, Bunkyo ku, Tokyo, Japan
Novartis Investigative Site, Shinjuku-ku, Tokyo, Japan
Novartis Investigative Site, Shinjuku-ku, Tokyo, Japan
Novartis Investigative Site, Seoul, Korea, Korea, Republic of
Novartis Investigative Site, Seoul, Seocho Gu, Korea, Republic of
Novartis Investigative Site, Seoul, , Korea, Republic of
Novartis Investigative Site, Seoul, , Korea, Republic of
Novartis Investigative Site, Kaohsiung, , Taiwan
Novartis Investigative Site, Taipei, , Taiwan
Novartis Investigative Site, Taoyuan, , Taiwan
Name: Novartis Pharmaceuticals
Affiliation: Novartis Pharmaceuticals
Role: STUDY_DIRECTOR