Spots Global Cancer Trial Database for Phase 2 Study: An Open-Label, Randomized, Phase 2 Dose-Finding Study of Pacritinib in Patients With Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis, or Post- Essential Thrombocythemia Myelofibrosis Previously Treated With Ruxolitinib
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Trial Identification
Brief Title: Phase 2 Study: An Open-Label, Randomized, Phase 2 Dose-Finding Study of Pacritinib in Patients With Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis, or Post- Essential Thrombocythemia Myelofibrosis Previously Treated With Ruxolitinib
Official Title: Phase 2 Study: An Open-Label, Randomized, Phase 2 Dose-Finding Study of Pacritinib in Patients With Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis, or Post- Essential Thrombocythemia Myelofibrosis Previously Treated With Ruxolitinib
Study ID: NCT04884191
Interventions
Study Description
Brief Summary: This was an open-label, randomized, dose-finding study in patients with primary or secondary MF (Dynamic International Prognostic Scoring System \[DIPSS\] risk score of Intermediate-1 to High-Risk) who were previously treated with ruxolitinib. The study was designed to support a pacritinib dosage selection decision with evaluation of 3 dosages.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Mayo Clinic Hospital, Phoenix, Arizona, United States
City of Hope, Duarte, California, United States
USC Norris Comprehensive Cancer Center, Los Angeles, California, United States
UCLA Jonsson Comprehensive Cancer Center, Los Angeles, California, United States
Stanford Cancer Institute, Stanford, California, United States
Yale School of Medicine, New Haven, Connecticut, United States
Medical Faculty Associates, Inc., Washington, District of Columbia, United States
Florida Cancer Specialists & Research Institute, Fort Myers, Florida, United States
Florida Cancer Specialists & Research Institute, Saint Petersburg, Florida, United States
Florida Cancer Specialists & Research Institute, West Palm Beach, Florida, United States
Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States
The University of Chicago Medical Center, Chicago, Illinois, United States
University of Kansas Cancer Center, Westwood, Kansas, United States
Ochsner Medical Center, New Orleans, Louisiana, United States
Saint Agnes Hospital, Baltimore, Maryland, United States
Dana-Farber Cancer Institute, Boston, Massachusetts, United States
University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, United States
Washington University School of Medicine in St. Louis, Saint Louis, Missouri, United States
Hackensack University Medical Center, Hackensack, New Jersey, United States
Weill Cornell Medical College, New York, New York, United States
Icahn School of Medicine at Mount Sinai, New York, New York, United States
Columbia University, New York, New York, United States
Memorial Sloan-Kettering Cancer Center, New York, New York, United States
University of Rochester, Rochester, New York, United States
Duke University Hospital, Durham, North Carolina, United States
Cleveland Clinic, Cleveland, Ohio, United States
The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States
Tennessee Oncology, Nashville, Tennessee, United States
Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, United States
The University of Texas MD Anderson Cancer Center, Houston, Texas, United States
University of Texas Health Science Center at San Antonio School of Medicine, San Antonio, Texas, United States
University of Utah School of Medicine, Salt Lake City, Utah, United States
Fred Hutchinson Cancer Research Center, Seattle, Washington, United States
CHU Hopital Sud, Amiens, , France
Centre Hospitalier Regional Universitaire de Lille - Hopital Claude Huriez, Lille Cedex, , France
CHU de Nimes - Hopital Universitaire Caremeau, Nîmes, , France
Hôpital Saint-Louis, Paris, , France
CHU Hopitaux de Bordeaux - Hôpital Haut-Lévêque, Pessac, , France
Centre Hospitalier Lyon-Sud, Pierre-Bénite, , France
Centre Hospitalier Universitaire de Toulouse- Hôpital Purpan, Toulouse Cedex, , France
SE AOK I. sx. Belgyogyaszati Klinika, Budapest, , Hungary
Debreceni Egyetem Klinikai Központ, Debrecen, , Hungary
Somogy Megyei Kaposi Mór Oktató Kórház, Kaposvár, , Hungary
Azienda Ospedaliero-Universitaria Careggi, Firenze, , Italy
Istituto Scientifico Romagnolo per lo Studio e la Cura Dei Tumori, Meldola, , Italy
ASST Monza - Ospedale San Gerardo, Monza, , Italy
Yeungnam University Medical Center, Daegu, , Korea, Republic of
Severance Hospital, Seoul, , Korea, Republic of
Samsung Medical Center, Seoul, , Korea, Republic of
The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, , Korea, Republic of
Hospital del Mar, Barcelona, , Spain
Hospital Clínic de Barcelona, Barcelona, , Spain
Hospital Universitario Ramón y Cajal, Madrid, , Spain
Clínica Universidad de Navarra, Pamplona, , Spain
Skane University Hospital Lund, Lund, , Sweden
Orebro University Hospital, Örebro, , Sweden
Beatson West of Scotland Cancer Center, Glasgow, , United Kingdom
Barts Health NHS Trust - The Royal London Hospital, London, , United Kingdom
Guy's and St Thomas' NHS Foundation Trust - Guy's Hospital, London, , United Kingdom
Imperial College Healthcare NHS Trust - Hammersmith Hospital, London, , United Kingdom
The Christie NHS Foundation Trust, Manchester, , United Kingdom
Oxford University Hospitals NHS Trust - Churchill Hospital, Oxford, , United Kingdom
Contact Details
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