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Brief Title: Safety and Tolerability Study of Oral NS-018 in Patients With Primary Myelofibrosis (MF), Post-polycythemia Vera MF or Post-essential Thrombocythemia MF
Official Title: A Phase 1/2, Open-label, Dose-Escalation Multi-center Study to Assess the Safety, Tolerability, PK and PD of Orally Administered NS-018 in Patients With Primary Myelofibrosis (MF), Post-polycythemia Vera MF, or Post-essential Thrombocythemia MF
Study ID: NCT01423851
Brief Summary: The purpose of this study is to determine the safety and tolerability of orally administered NS-018 in patients with Primary Myelofibrosis (PMF), Post-polycythemia Vera Myelofibrosis (post-PV MF), or Post-essential Thrombocythemia Myelofibrosis (post-ET MF)
Detailed Description: This is a Phase 1/2 study that is currently enrolling Janus kinase 2 (JAK2) failures into the Phase 2 portion of the study.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Mayo Clinic Scottsdale Recruiting, Scottsdale, Arizona, United States
UC San Diego Moores Cancer Center, San Diego, California, United States
Mayo Clinic, Jacksonville, Jacksonville, Florida, United States
Northwestern University, Chicago, Illinois, United States
University of Chicago, Chicago, Illinois, United States
Dana Farber Cancer Institute, Boston, Massachusetts, United States
University of Michigan, Ann Arbor, Michigan, United States
Weill Cornell Medical College, New York, New York, United States
MD Anderson Cancer Center, Department of Leukemia, Houston, Texas, United States
Name: Srdan Verstovsek, M.D., Ph.D.
Affiliation: MD Anderson Cancer Center, Houston, TX, 77030
Role: PRINCIPAL_INVESTIGATOR