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Spots Global Cancer Trial Database for Safety and Tolerability Study of Oral NS-018 in Patients With Primary Myelofibrosis (MF), Post-polycythemia Vera MF or Post-essential Thrombocythemia MF

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Trial Identification

Brief Title: Safety and Tolerability Study of Oral NS-018 in Patients With Primary Myelofibrosis (MF), Post-polycythemia Vera MF or Post-essential Thrombocythemia MF

Official Title: A Phase 1/2, Open-label, Dose-Escalation Multi-center Study to Assess the Safety, Tolerability, PK and PD of Orally Administered NS-018 in Patients With Primary Myelofibrosis (MF), Post-polycythemia Vera MF, or Post-essential Thrombocythemia MF

Study ID: NCT01423851

Interventions

NS-018

Study Description

Brief Summary: The purpose of this study is to determine the safety and tolerability of orally administered NS-018 in patients with Primary Myelofibrosis (PMF), Post-polycythemia Vera Myelofibrosis (post-PV MF), or Post-essential Thrombocythemia Myelofibrosis (post-ET MF)

Detailed Description: This is a Phase 1/2 study that is currently enrolling Janus kinase 2 (JAK2) failures into the Phase 2 portion of the study.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Mayo Clinic Scottsdale Recruiting, Scottsdale, Arizona, United States

UC San Diego Moores Cancer Center, San Diego, California, United States

Mayo Clinic, Jacksonville, Jacksonville, Florida, United States

Northwestern University, Chicago, Illinois, United States

University of Chicago, Chicago, Illinois, United States

Dana Farber Cancer Institute, Boston, Massachusetts, United States

University of Michigan, Ann Arbor, Michigan, United States

Weill Cornell Medical College, New York, New York, United States

MD Anderson Cancer Center, Department of Leukemia, Houston, Texas, United States

Contact Details

Name: Srdan Verstovsek, M.D., Ph.D.

Affiliation: MD Anderson Cancer Center, Houston, TX, 77030

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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