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Spots Global Cancer Trial Database for Molecular PET/MR Imaging in Vivo Validation of Biomarker for Human Prostate Cancer

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Trial Identification

Brief Title: Molecular PET/MR Imaging in Vivo Validation of Biomarker for Human Prostate Cancer

Official Title: Molecular PET/MR Imaging in Vivo Validation of Biomarker for Human Prostate Cancer

Study ID: NCT03451812

Interventions

Study Description

Brief Summary: Primary objective: To correlate the blood/urine metabolomic biomarkers with PET/MR imaging. Secondary objectives: 1. To evaluate the sensitivity and specificity of the PET/MR in diagnosis of prostate cancer. 2. To examine the diagnostic performance among subgroups of defined high-risk and low-risk subjects. 3. To interrogate the metabolomic alterations with the molecular PET/MR to develop workable panel biomarkers.

Detailed Description: According to 2015 National Comprehensive Cancer Network (NCCN) guideline, medical imaging plays important roles for detection and staging for PCa, in addition to blood or urine biomarkers. Although there are a number of very different diagnostic imaging methods, e.g. transrectal ultrasound (TRUS), computed tomography (CT), magnetic resonance (MR) imaging and spectroscopy, or 18F-FDG positron emission tomography (PET), none of these have gained a dominant role as the optimum method for all clinical scenarios.The recently added armamentarium, PET/MR, might improve diagnosis in this regard. Therefore, we conduct this trial to identify the ability of \[11C\]Choline PET/MR to evaluate the patients with prostate cancer, especially under the circumstance of elevated PSA level.

Eligibility

Minimum Age: 40 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: MALE

Healthy Volunteers: No

Locations

Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital, Guishan, Taoyuan, Taiwan

Contact Details

Name: Gigin Lin, MD, PhD

Affiliation: Medical Imaging and Intervention, Chang Gung Memorial Hospital

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

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