Spots Global Cancer Trial Database for Metastatic Prostate Cancer Men's Attitudes Towards Treatment of the Local Tumour and Metastasis Evaluative Research
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Trial Identification
Brief Title: Metastatic Prostate Cancer Men's Attitudes Towards Treatment of the Local Tumour and Metastasis Evaluative Research
Official Title: Patients' Preferences in the Treatment of Hormone-sensitive Metastatic Prostate Cancer: a Discrete Choice Experiment
Study ID: NCT04590976
Study Description
Brief Summary: Systemic therapy (i.e Androgen Deprivation Therapy with Docetaxel, Enzalutamide, Apalutamide or Abiraterone Acetate) has increased overall survival in men with hormone-sensitive metastatic prostate cancer. Novel local cytoreductive treatments and metastasis directed therapy are being evaluated, these can confer additional harm, but might improve survival. We aim to elicit men's preferences for and willingness to accept trade-offs between potential improved survival and cytoreductive treatment risks using a 'discrete choice experiment'.
Detailed Description: OBJECTIVES: To determine the attributes associated with treatment that are most important to men with hormone-sensitive metastatic prostate cancer (mPCa). To determine men's preferences for, and trade-offs between, the attributes (survival and side-effects) of different treatment options in metastatic prostate cancer including systemic therapy, local and metastases-directed physical therapies. PHASE: Prospective multi-centre observational cohort DESIGN: Discrete choice experiment, single-visit, electronic questionnaire design SAMPLE SIZE: Multi-centre Stage (Stage 3) n = 300 patients POPULATION: Men with newly-diagnosed metastatic prostate cancer who have not consented to a form of local cytoreductive or metastasis directed therapy.
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: MALE
Healthy Volunteers: No
Locations
NHS Grampion, Aberdeen, , United Kingdom
Besti Cadwaladr University, Bangor, , United Kingdom
Ysbyty Gwynedd Hospital, Bangor, , United Kingdom
Hamphire Hospitals NHS Foundation Trust, Basingstoke, , United Kingdom
Royal Bath United Hospital, Bath, , United Kingdom
Bedford Hospital, Bedford, , United Kingdom
Royal Bolton Hospital, Bolton, , United Kingdom
Brighton and Sussex hospital, Brighton, , United Kingdom
East Suffolk and North Essex NHS Foundation Trust, Colchester, , United Kingdom
Dartford and Gravsham NHS Trust, Dartford, , United Kingdom
Royal Devon and Exeter Hospital, Exeter, , United Kingdom
Medway NHS Foundation Trust, Gillingham, , United Kingdom
Northern Lincolnshire and Goole NHS Foundation Trust, Grimsby, , United Kingdom
Royal Surrey County Hospital NHS Foundation Trust, Guildford, , United Kingdom
Imperial College London, Hammersmith, , United Kingdom
North Tees and Hartlepool NHS Foundation Trust, Hartlepool, , United Kingdom
West Middlesex University Hospital, Isleworth, , United Kingdom
Queen Elizabeth Hospital, King's Lynn, , United Kingdom
Kingston Hospital NHS Foundation Trust, Kingston, , United Kingdom
Chelsea and Westminster Hospital, London, , United Kingdom
Imperial College Healthcare NHS Trust, London, , United Kingdom
The Royal Marsden NHS Foundation Trust, Chelsea Research Centre, London, , United Kingdom
Luton and Dunstable University Hospital, Luton, , United Kingdom
Freeman Hospital, Newcastle, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, , United Kingdom
Nottingham University Hospital, Nottingham, , United Kingdom
University Hospitals Dorset NHS Foundation Trust, Poole, , United Kingdom
East Surrey Hospital, Redhill, , United Kingdom
Royal Shrewsbury Hospital, Shrewsbury, , United Kingdom
Southampton General Hospital, University Hospital Southampton NHS Foundation Trust (UHS), Southampton, , United Kingdom
East and North Hertfordshire Nhs Trust, Stevenage, , United Kingdom
Sunderland Royal Hospital, City Hospitals Sunderland NHS Foundation Trust, Sunderland, , United Kingdom
Musgrove Park Hospital - Somerset NHS Foundation Trust, Taunton, , United Kingdom
The Royal Cornwall Hospital, Truro, , United Kingdom
Wirral University Teaching Hospital Nhs Foundation, Wirral, , United Kingdom
Wrexham Maelor, Wrexham, , United Kingdom
Contact Details
Name: Hashim Ahmed, PhD, FRCS
Affiliation: Imperial College London
Role: PRINCIPAL_INVESTIGATOR
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