Spots Global Cancer Trial Database for S0000 Selenium and Vitamin E in Preventing Prostate Cancer
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Trial Identification
Brief Title: S0000 Selenium and Vitamin E in Preventing Prostate Cancer
Official Title: Selenium and Vitamin E Cancer Prevention Trial (SELECT) for Prostate Cancer
Study ID: NCT00006392
Conditions
Study Description
Brief Summary: RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development of cancer. It is not yet known which regimen of selenium and/or vitamin E may be more effective in preventing prostate cancer. PURPOSE: Randomized phase III trial to determine the effectiveness of selenium and vitamin E, either alone or together, in preventing prostate cancer.
Detailed Description: OBJECTIVES: * Compare the effect of selenium and vitamin E administered alone vs in combination on the clinical incidence of prostate cancer. * Compare the effect of these prevention regimens on the incidence of lung cancer, colorectal cancer, and all cancers combined in participants on this study. * Compare the effect of these prevention regimens on prostate cancer-free survival, lung cancer-free survival, colorectal cancer-free survival, cancer-free survival, overall survival, and serious cardiovascular events in these participants.
Keywords
Eligibility
Minimum Age: 50 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: MALE
Healthy Volunteers: Yes
Locations
Robert H. Lurie Comprehensive Cancer Center at Northwestern University, Chicago, Illinois, United States
Midwest Center for Hematology/Oncology, Joliet, Illinois, United States
Cardinal Bernardin Cancer Center at Loyola University Medical Center, Maywood, Illinois, United States
CCOP - Cancer Research for the Ozarks, Springfield, Missouri, United States
St. John's Regional Health Center, Springfield, Missouri, United States
Good Samaritan Hospital Cancer Treatment Center, Cincinnati, Ohio, United States
Bethesda North Hospital, Cincinnati, Ohio, United States
Tod Children's Hospital, Youngstown, Ohio, United States
LaFortune Cancer Center at St. John Medical Center, Tulsa, Oklahoma, United States
Geisinger Medical Center, Danville, Pennsylvania, United States
Geisinger Medical Group - Scenery Park, State College, Pennsylvania, United States
Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center, Wilkes-Barre, Pennsylvania, United States
U.T. Cancer Institute at University of Tennessee Medical Center, Knoxville, Tennessee, United States
Contact Details
Name: Eric Klein, MD
Affiliation: The Cleveland Clinic
Role: STUDY_CHAIR
Name: Philip J. Walther, MD, PhD
Affiliation: Duke University
Role: STUDY_CHAIR
Name: Laurence H. Klotz, MD
Affiliation: Toronto Sunnybrook Regional Cancer Centre
Role: STUDY_CHAIR
Name: Scott M. Lippman, M.D.
Affiliation: MD Anderson
Role: STUDY_CHAIR
Name: Ian M. Thompson, M.D.
Affiliation: University of Texas
Role: STUDY_CHAIR
Name: J. Michael Gaziano, M.D.
Affiliation: MAVERIC
Role: STUDY_CHAIR
Name: Daniel D Karp, M.D.
Affiliation: Beth Israel Deaconess
Role: STUDY_CHAIR
Name: Fadlo R. Khuri, M.D.
Affiliation: MD Anderson
Role: STUDY_CHAIR
Name: Michael M Lieber, M.D.
Affiliation: Mayo Clinic
Role: STUDY_CHAIR
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