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Spots Global Cancer Trial Database for High Precision Imaging of Prostate Specific Membrane Antigen for Personalized Treatment in Prostate Cancer

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Trial Identification

Brief Title: High Precision Imaging of Prostate Specific Membrane Antigen for Personalized Treatment in Prostate Cancer

Official Title: High Precision Imaging of Prostate Specific Membrane Antigen for Personalized Treatment in Prostate Cancer

Study ID: NCT03327675

Conditions

Prostate Cancer

Study Description

Brief Summary: This is an Investigator Initiated, non-commercial, single center, non-randomized, single arm, open label pilot study on 194 patients. The patients are affected by prostate cancer but in two different clinical settings. The first group is characterized by patients who are going to be operated of radical prostatectomy and they will undergo the study imaging preoperatively. The second group experiences biochemical relapse after primary treatment.

Detailed Description: Novel, sensitive tools, such as 68Ga-PSMA PET imaging, have great potential for very early disease detection and open the possibility of early curative local salvage treatment (with surgery, radiotherapy or a combination of both). This project will moreover provide important insights into the biodistribution and dosimetry of 68Ga-PSMA, opening possibilities of 90-Yttrium or 177-Lutetium-PSMA-based radionuclidetherapy of patients with metastatic PC in the future. The study consists of 2 work units (WU): Work-unit 1: Patients at high risk for nodal involvement prior to radical prostatectomy with extended lymph node dissection Work-unit 2: Biochemical recurrence after initial treatment with curative intent

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: MALE

Healthy Volunteers: No

Locations

UZLeuven, Leuven, , Belgium

Contact Details

Name: Karolien Goffin, MD, PhD

Affiliation: UZ Leuven

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

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