Spots Global Cancer Trial Database for Evaluation of Lithium and It's Effect on Clinically Localized Prostate Cancer

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Trial Identification

Brief Title: Evaluation of Lithium and It's Effect on Clinically Localized Prostate Cancer

Official Title: Phase 1 Study of Evaluation of Lithium and it's Effect on Clinically Localized Prostate Cancer.

Study ID: NCT02198859

Conditions

Prostate Cancer

Interventions

Lithium Carbonate

Study Description

Brief Summary: Laboratory testing has suggested that lithium may decrease the incidence of certain types of cancer, including prostate cancer. Additional research has suggested that lithium decreases prostate cancer tumor size over time. This study will investigate the effect of lithium on men with prostate cancer.

Detailed Description: As lithium has been shown in an in vitro model to suppress cellular proliferation, and suppress tumor growth in an in vivo xenograft model, we propose to determine its effect on prostate cancer cells in human patients undergoing radical prostatectomy. In this pilot study we plan to assess the toxicity of lithium administration in patients prior to radical prostatectomy. This will include any clinical toxicity as well as any increase in intra-, peri- or postoperative complications.