Spots Global Cancer Trial Database for Degarelix Before Radical Prostatectomy
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Trial Identification
Brief Title: Degarelix Before Radical Prostatectomy
Official Title: A Study of the Early Biological Effects of Testosterone Suppression in Prostate Cancer Using Neoadjuvant Degarelix Prior to Radical Prostatectomy
Study ID: NCT01852864
Conditions
Interventions
Study Description
Brief Summary: The biological effects of castration on prostate cancers will be studies by administration of degarelix prior to radical prostatectomy. The effects will be studied by analysis of gene expression and immunohistochemistry focusing on markers of proliferation and apoptosis of samples taken at the time of radical prostatectomy (7 days after administration of degarelix). Tumours from patients treated with neo-adjuvant degarelix will be compared with tumours from patients who have not been medically castrated.
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: MALE
Healthy Volunteers: No
Locations
Cambridge University Hopital NHS Trust, Cambridge, Cambridgeshire, United Kingdom
Contact Details
Name: David Neal, BSc MS FRCS
Affiliation: Cambridge University
Role: STUDY_CHAIR
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