Spots Global Cancer Trial Database for The Effect of Propofol Based Total Intravenous Anesthesia on Oxidative Stress and Nitric Oxide
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Trial Identification
Brief Title: The Effect of Propofol Based Total Intravenous Anesthesia on Oxidative Stress and Nitric Oxide
Official Title: The Effect of Propofol Based Total Intravenous Anesthesia on Oxidative Stress and Nitric Oxide in Patients Undergoing Laparoscopic Surgery
Study ID: NCT02149628
Conditions
Study Description
Brief Summary: Robot assisted laparoscopic radical prostatectomy(Robot-LRP) requires pneumoperitoneum and trendelenburg position which result in oxidative stress and inflammatory response. Propofol is well known to reduce those responses during anesthesia. Therefore, we try to figure out the efficacy of propofol to reduce oxidative stress, inflammatory response and increase the nitric oxide activity during robot-LRP compared to that of desflurane. To investigate the oxidative stress, malondialdehyde will be measured. As inflammatory markers, interleukin-1β, interleukin-6, tumor necrosis factor-α will be measured. Nitric oxide will be measured as well. Secondarily, kidney protection effect of propofol over desflurane will be compared.
Detailed Description:
Keywords
Eligibility
Minimum Age: 20 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: MALE
Healthy Volunteers: No
Locations
Yonsei University, Gangnam Severance Hospital, Seoul, , Korea, Republic of
Contact Details
Name: Goun Roh, MD
Affiliation: Yonsei University Gangnam Severance Hospital
Role: PRINCIPAL_INVESTIGATOR
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