Spots Global Cancer Trial Database for Study of Cabozantinib (XL184) Versus Mitoxantrone Plus Prednisone in Men With Previously Treated Symptomatic Castration-resistant Prostate Cancer
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Trial Identification
Brief Title: Study of Cabozantinib (XL184) Versus Mitoxantrone Plus Prednisone in Men With Previously Treated Symptomatic Castration-resistant Prostate Cancer
Official Title: A Phase 3, Randomized, Double-blind, Controlled Trial of Cabozantinib (XL184) Versus Mitoxantrone Plus Prednisone in Men With Previously Treated Symptomatic Castration-resistant Prostate Cancer
Study ID: NCT01522443
Study Description
Brief Summary: Bone metastases and associated pain are a major cause of morbidity and mortality in castration-resistant prostate cancer (CRPC). Most approved therapies have shown some ability to reduce soft tissue lesions but none meaningfully impacts bone metastases (as demonstrated by lack of resolution of lesions on bone scan with these agents) or the pain associated with these metastases. This study will evaluate the effect of cabozantinib versus mitoxantrone plus prednisone on pain response and bone scan response in men with CRPC.
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: MALE
Healthy Volunteers: No
Locations
, Scottsdale, Arizona, United States
, La Jolla, California, United States
, Los Angeles, California, United States
, Los Angeles, California, United States
, Marina Del Rey, California, United States
, San Diego, California, United States
, San Francisco, California, United States
, Santa Barbara, California, United States
, Stanford, California, United States
, Aurora, Colorado, United States
, Littleton, Colorado, United States
, Washington, District of Columbia, United States
, Boca Raton, Florida, United States
, Athens, Georgia, United States
, Chicago, Illinois, United States
, Indianapolis, Indiana, United States
, Iowa City, Iowa, United States
, Westwood, Kansas, United States
, Louisville, Kentucky, United States
, New Orleans, Louisiana, United States
, Baltimore, Maryland, United States
, Detroit, Michigan, United States
, Detroit, Michigan, United States
, Minneapolis, Minnesota, United States
, Tupelo, Mississippi, United States
, Saint Louis, Missouri, United States
, Omaha, Nebraska, United States
, Las Vegas, Nevada, United States
, New Brunswick, New Jersey, United States
, Buffalo, New York, United States
, New York, New York, United States
, New York, New York, United States
, New York, New York, United States
, Chapel Hill, North Carolina, United States
, Durham, North Carolina, United States
, Raleigh, North Carolina, United States
, Cleveland, Ohio, United States
, Oklahoma City, Oklahoma, United States
, Pittsburgh, Pennsylvania, United States
, Watertown, South Dakota, United States
, Memphis, Tennessee, United States
, Nashville, Tennessee, United States
, Dallas, Texas, United States
, Round Rock, Texas, United States
, Salt Lake City, Utah, United States
, Norfolk, Virginia, United States
, Seattle, Washington, United States
, Madison, Wisconsin, United States
, Milwaukee, Wisconsin, United States
, Concord, New South Wales, Australia
, Darlinghurst, New South Wales, Australia
, Kogarah, New South Wales, Australia
, Port Macquarie, New South Wales, Australia
, Randwick, New South Wales, Australia
, Wahroonga, New South Wales, Australia
, Milton, Queensland, Australia
, South Brisbane, Queensland, Australia
, Woolloongabba, Queensland, Australia
, Box Hill, Victoria, Australia
, Wodonga, Victoria, Australia
, Subiaco, Western Australia, Australia
, Kelowna, British Columbia, Canada
, Vancouver, British Columbia, Canada
, London, Ontario, Canada
, Toronto, Ontario, Canada
, Toronto, Ontario, Canada
, Dublin, , Ireland
, Dublin, , Ireland
, Bath, England, United Kingdom
, Cambridge, England, United Kingdom
, Leeds, England, United Kingdom
, London, England, United Kingdom
, London, England, United Kingdom
, London, England, United Kingdom
, Manchester, England, United Kingdom
, Sutton, England, United Kingdom
, Wirral, England, United Kingdom
, Aberdeen, Scotland, United Kingdom
, Edinburgh, Scotland, United Kingdom
, Glasgow, Scotland, United Kingdom
, Inverness, Scotland, United Kingdom
, Belfast, , United Kingdom
Contact Details
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