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Spots Global Cancer Trial Database for Study to Monitor the Effects of Androgen Suppression Treatment on the Heart

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Trial Identification

Brief Title: Study to Monitor the Effects of Androgen Suppression Treatment on the Heart

Official Title: Does Androgen Suppression Treatment In Prostate Cancer Reduce Myocardial Blood Flow Reserve?

Study ID: NCT01230905

Conditions

Prostate Cancer

Study Description

Brief Summary: Suppression of effects of androgens with male sex hormones, androgen suppression treatment (AST), has been known to reduce deaths and prolong life in advanced prostate cancer. There have, however, been concerns raised in previous studies that androgen suppression may be associated with increased rate of heart attacks, particularly in older men. This study looks at prostate cancer patients in The Ottawa Hospital Cancer Clinic to see if treating these patients with androgen suppression is associated with a decrease in blood flow to the heart muscles by using Positron Emission Tomography (PET) and brachial artery ultrasound.

Detailed Description: Treatment group: Prior to the initiation of AST, subjects will have a baseline N-13-ammonia PET scan and a brachial artery ultrasound at the University of Ottawa Heart Institute. Blood glucose and a lipid profile will be obtained. These tests will be repeated 6 - 9 months after starting AST. Cancer control group: The same testing and intervals will be performed. Normals control group: Baseline testing will be done to establish a normal.

Eligibility

Minimum Age: 40 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: MALE

Healthy Volunteers: Yes

Locations

University of Ottawa Heart Institute, Ottawa, Ontario, Canada

Contact Details

Name: Terrence Ruddy, MD

Affiliation: Ottawa Heart Institute Research Corporation

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

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