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Spots Global Cancer Trial Database for Development and Validation of Novel MRI Methods for the Detection of Prostate Cancer Aggressiveness

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Trial Identification

Brief Title: Development and Validation of Novel MRI Methods for the Detection of Prostate Cancer Aggressiveness

Official Title: Development and Validation of Novel MRI Methods for the Detection of Prostate Cancer Aggressiveness

Study ID: NCT02545881

Conditions

Prostate Cancer

Study Description

Brief Summary: The purpose of this study is to develop, validate, and evaluate the correlation of novel magnetic resonance imaging (MRI) methods with prostate cancer aggressiveness and histological data obtained during prostatectomy.

Detailed Description: Prostate cancer is one of the most common neoplastic diseases in men. Prostate specific antigen (PSA) has only a limited role in the diagnosis and characterization of prostate cancer. The diagnosis of prostate cancer is still most commonly done by transrectal ultrasonography (TRUS) guided biopsy. However, TRUS guided biopsy carries a risk of increase in complications. There is an increasing interest in developing more accurate non-invasive imaging modalities which could potentially detect prostate cancer aggressiveness. Diffusion weighted imaging (DWI) and rotating frame relaxation measurements have shown to be particularly promising in prostate cancer detection and characterization. This study which focuses on further development and validation of DWI and rotating frame relaxation measurements will enroll 200 men with histologically diagnosed prostate cancer who will undergo magnetic resonance imaging (MRI) before prostatectomy. Anatomical MRI and novel acquisition methods focusing on DWI and rotating frame relaxation measurements will be performed using surface coils to non-invasively detect and characterize prostate cancer.

Keywords

Eligibility

Minimum Age: 30 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: MALE

Healthy Volunteers: No

Locations

Department of Urology, Turku University Hospital, Turku, , Finland

Contact Details

Useful links and downloads for this trial

Clinicaltrials.gov

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