Spots Global Cancer Trial Database for Application of DWI in Diagnosis of Prostate Cancer

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Application of DWI in Diagnosis of Prostate Cancer

Official Title: Different Models of Multiple B-value DWI and Their Applications in Diagnosis of Prostate Cancer

Study ID: NCT04962269

Conditions

Prostate Cancer

Benign Prostatic Hyperplasia

Interventions

MRI

Study Description

Brief Summary: This study compared the performance of different models of multiple b-value DWI in diagnosing prostate cancer.

Detailed Description: Diffusion weighted imaging (DWI) plays an important role in the diagnosis and stratification of prostate cancer. Traditional DWI apply the apparent diffusion coefficient (ADC) to reflect the diffusion of tissue water, which is a parameter calculated by a monoexponential model with 2b values. In recent years, the development of multiple b-value DWI facilitates the appearance of many new mathematical models. Different models have different features, but their value of applications in prostate cancer still need to be confirmed. This study was aiming to: (1) compare the parameters derived from monoexponential model, intravoxel incoherent motion (IVIM) model and stretched exponential model between prostate cancer and benign prostatic hyperplasia; (2) compare the difference of these parameters between low-grade (Gleason score ≤ 3+4) and high-grade (Gleason score ≥ 4+3) cancer; (3) find whether these parameters derived from new models are superior to ADC derived from traditional monoexponetial model.