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Spots Global Cancer Trial Database for Effects of ASA on Prostate Tissue

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We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Effects of ASA on Prostate Tissue

Official Title: In Vivo Molecular Effects of Aspirin on Prostate Tissue

Study ID: NCT00234299

Conditions

Prostate Cancer

Interventions

Aspirin
Placebo

Study Description

Brief Summary: Aspirin affects many physiological processes through its anti-inflammatory actions. Various cancers, including prostate cancer, appear to utilize inflammatory signals to facilitate their growth and progression. We hypothesize that oral aspirin acts directly on prostate epithelial cells to alter COX-2-related metabolism and inhibit prostate cell growth.

Detailed Description: Prostate cancer is the most common non-cutaneous malignancy in men and is the second leading cause of cancer death among U.S. men. 221,000 new cases and 29,000 deaths are expected in 2003. The incidence of prostate cancer diagnosis is increasing at 3% per year. Prostate specific antigen (PSA) screening has resulted in improvements in early diagnosis of prostate cancer. However, available treatments all may have a significant negative effect on quality of life. Studies have implicated a beneficial association between ASA use and a lower risk of other types of malignancies, including stomach, esophageal, breast, ovarian, and prostate cancer. There is significant evidence to suggest that aspirin has a protective effect against prostate cancer.

Eligibility

Minimum Age: 45 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: MALE

Healthy Volunteers: Yes

Locations

VA Puget Sound Health Care Service, Seattle, Washington, United States

Contact Details

Name: Daniel W Lin, MD

Affiliation: Veteran's Administration Puget Sound Health Care Service

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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