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Spots Global Cancer Trial Database for Early Prostate Cancer: Predicting Treatment Response

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We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Early Prostate Cancer: Predicting Treatment Response

Official Title: Precision Medicine for Early Prostate Cancer: Integrating Biological and Patient Complexity Variables to Predict Treatment Response

Study ID: NCT03770351

Conditions

Prostate Cancer

Interventions

Study Description

Brief Summary: This study will replicate/validate the risk prediction model developed for the Comparative Effectiveness Analysis of Surgery and Radiation (CEASAR) study in a more diverse patient population to assess generalizability of the model as well as evaluate the relative contribution of the Decipher Prostate Cancer Test and ProstateNext Test from Ambry Genetics, to the risk prediction model for estimating treatment outcomes, and thereby improve personalization of treatment options.

Detailed Description: The study will contribute a replicable model for improving risk prediction from patient characteristics, clinical severity indicators, and genomic tests to aid in personalizing treatment. The proposed registry would also allow future comparisons of the gene expression used in other competing commercial test. The addition of the suggested genomic classifier and its associations with other patient and clinical characteristics will enhance the ability of future studies, analogous to CEASAR, to accurately predict the risk of tumor aggressiveness in prostate cancer.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: MALE

Healthy Volunteers: No

Locations

University of California, Irvine, Irvine, California, United States

Veterans Affair Long Beach Healthcare System, Long Beach, California, United States

Cedars-Sinai Medical Center, Los Angeles, California, United States

University of California, Los Angeles, Los Angeles, California, United States

Veterans Affair West Los Angeles Healthcare System, West Los Angeles, California, United States

Contact Details

Name: Sheldon Greenfield

Affiliation: University of California, Irvine

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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