Spots Global Cancer Trial Database for Rucaparib and Nivolumab in Patients With Prostate or Endometrial Cancer
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Trial Identification
Brief Title: Rucaparib and Nivolumab in Patients With Prostate or Endometrial Cancer
Official Title: A Phase Ib/IIa Study of Rucaparib (PARP Inhibitor) Combined With Nivolumab in Metastatic Castrate - Resistant Prostate Cancer and Advanced/Recurrent Endometrial Cancer
Study ID: NCT03572478
Study Description
Brief Summary: This is a phase 1/phase 2a study of the combination of immune checkpoint inhibitor (nivolumab) in combination with the PARP inhibitor (rucaparib) for patients with metastatic castration resistant prostate cancer (mCRPC) and metastatic/recurrent endometrial cancer. In the phase 1 portion, the safety of the combination dosing will be determined. If the combination dosing is determined to be safe and feasible, the study will move onto phase 2a. In the phase 2a portion, participants will be randomized to receive either: rucaparib alone, nivolumab alone, or combination therapy (rucaparib and nivolumab).
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
University of Chicago Medical Center, Chicago, Illinois, United States
Contact Details
Name: Walter Stadler, MD
Affiliation: University of Chicago
Role: PRINCIPAL_INVESTIGATOR
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