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Brief Title: Hormone Therapy With or Without Docetaxel And Estramustine in Treating Patients With Prostate Cancer That is Locally Advanced or At High Risk of Relapse
Official Title: Phase III Randomized Study Of Adjuvant Hormonal Therapy With And Without Docetaxel And Estramustine In Patients With Advanced Prostate Cancer Or With A High Risk Of Relapse
Study ID: NCT00055731
Brief Summary: RATIONALE: Androgens can stimulate the growth of prostate cancer cells. Drugs such as nilutamide, bicalutamide, flutamide, or cyproterone may stop the adrenal glands from producing androgens. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known whether hormone therapy is more effective with or without chemotherapy in treating prostate cancer. PURPOSE: Randomized phase III trial to compare the effectiveness of hormone therapy with or without docetaxel and estramustine in treating patients who have prostate cancer that is locally advanced or at high risk of relapse.
Detailed Description:
Minimum Age: 0 Years
Eligible Ages: CHILD, ADULT, OLDER_ADULT
Sex: MALE
Healthy Volunteers: No
Centre Paul Papin, Angers, , France
Hopital Saint Andre, Bordeaux, , France
Institut Bergonie, Bordeaux, , France
Hopital Ambroise Pare, Boulogne-Billancourt, , France
Centre Regional Francois Baclesse, Caen, , France
Polyclinique du Parc, Cholet, , France
Centre Hospitalier Universitaire Henri Mondor, Creteil, , France
Clinique Sainte-Marguerite, Hyeres, , France
Centre Hospitalier Departemental, La Roche Sur Yon, , France
Centre Hospital Universitaire Hop Huriez, Lille, , France
Centre Hospital Regional Universitaire de Limoges, Limoges, , France
Polyclinique des Quatre Pavillons, Lormont, , France
Centre Leon Berard, Lyon, , France
Marseille Institute of Cancer - Institut J. Paoli and I. Calmettes, Marseille, , France
CHU de la Timone, Marseille, , France
Hopital Notre-Dame de Bon Secours, Metz, , France
Hopital Clinique Claude Bernard, Metz, , France
Centre Hospitalier General de Mont de Marsan, Mont-de-Marsan, , France
Hopital Lapeyronie-CHU Montpellier, Montpellier, , France
Centre Regional de Lutte Contre le Cancer - Centre Val d'Aurelle, Montpellier, , France
Centre Catherine de Sienne, Nantes, , France
Centre Antoine Lacassagne, Nice, , France
Hopital Europeen Georges Pompidou, Paris, , France
Hopital de la Croix St. Simon, Paris, , France
Institut Curie Hopital, Paris, , France
Hopital Saint Joseph, Paris, , France
Hopital Tenon, Paris, , France
Institut Jean Godinot, Reims, , France
Centre Eugene Marquis, Rennes, , France
Centre Hospitalier de Rodez, Rodez, , France
Centre Henri Becquerel, Rouen, , France
Centre Rene Huguenin, Saint Cloud, , France
CRLCC Nantes - Atlantique, Saint-Herblain, , France
Hopital Foch, Suresnes, , France
Institut Claudius Regaud, Toulouse, , France
Centre Hospitalier Universitaire Bretonneau de Tours, Tours, , France
Centre Alexis Vautrin, Vandoeuvre-les-Nancy, , France
Institut Gustave Roussy, Villejuif, , France
Name: Karim Fizazi, MD, PhD
Affiliation: Gustave Roussy, Cancer Campus, Grand Paris
Role: STUDY_CHAIR