Spots Global Cancer Trial Database for Allogeneic Human Bone Marrow Derived Mesenchymal Stem Cells in Localized Prostate Cancer
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Trial Identification
Brief Title: Allogeneic Human Bone Marrow Derived Mesenchymal Stem Cells in Localized Prostate Cancer
Official Title: A Phase 1 Study of Allogeneic Human Bone Marrow Derived Mesenchymal Stem Cells in Localized Prostate Cancer
Study ID: NCT01983709
Conditions
Interventions
Study Description
Brief Summary: The objective of this study is to determine if systemically infused allogeneic bone marrow derived mesenchymal stem cells (MSC) home to sites of prostate cancer in men with localized adenocarcinoma of the prostate that are planning to undergo a prostatectomy. Investigators plan to systemically infuse MSCs 4, 6 or 8 days prior to enrolled subjects' planned prostatectomies. Investigators will then quantify the relative amount of donor MSC DNA to recipient DNA present in patients' explanted prostate specimens. This will be accomplished via BEAMing digital PCR. This trial will provide the foundation for future studies aimed at engineering MSCs to deliver a toxin to sites of metastatic prostate cancer.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: MALE
Healthy Volunteers: Yes
Locations
Johns Hopkins Hospital, Baltimore, Maryland, United States
Contact Details
Name: Samuel Denmeade, MD
Affiliation: Johns Hopkins University
Role: PRINCIPAL_INVESTIGATOR
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