Spots Global Cancer Trial Database for Role of Soy Supplementation in Prostate Cancer Development

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Trial Identification

Brief Title: Role of Soy Supplementation in Prostate Cancer Development

Official Title: Role of Soy Isoflavones in Prostate Cancer Prevention

Study ID: NCT00255125

Conditions

Prostate Neoplasm

Interventions

Soy Supplement

Placebo

Study Description

Brief Summary: This is a randomized study evaluating the effectiveness and direct effect a commercial soy supplement has on prostate cancer and normal prostate tissue. Patient will be randomized it either receive placebo or a commercial soy supplement for 2-4 weeks prior to the planned surgery for treatment of their prostate cancer. Patient's blood and prostate tissue will be evaluated to determine the effects of the soy supplement on the prostate tissue.

Detailed Description: This is a randomized study evaluating the effectiveness and direct effect a commercial soy supplement has on prostate cancer and normal prostate tissue. Patients will be randomized to either receive placebo or a commercial soy supplement for 2-4 weeks prior to the planned surgery for treatment of their prostate cancer. The specific objectives are: 1. To assess the effect of soy supplementation on endogenous hormone production levels and serum prostate specific antigens. 2. To assess the impact of soy supplementation on estrogen receptor expression(ER). 3. To determine the impact of soy isoflavones on cell cycle regulation and associated gene expression.