Spots Global Cancer Trial Database for DECAMP 1 PLUS: Prediction of Lung Cancer Using Noninvasive Biomarkers
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Trial Identification
Brief Title: DECAMP 1 PLUS: Prediction of Lung Cancer Using Noninvasive Biomarkers
Official Title: DECAMP 1 PLUS: Prediction of Lung Cancer Using Noninvasive Biomarkers
Study ID: NCT04165564
Conditions
Study Description
Brief Summary: DECAMP 1 PLUS aims to improve the efficiency of the diagnostic evaluation of patients with indeterminate pulmonary nodules (8-25 mm). Molecular biomarkers for lung cancer diagnosis measured in minimally invasive and non-invasive biospecimens may be able to distinguish between malignant or benign indeterminate pulmonary nodules in high-risk smokers. Ultimately, this study aims to validate molecular as well as clinical and imaging biomarkers of lung cancer in individuals with indeterminate lung nodules.
Detailed Description: The Detection of Early lung Cancer Among Military Personnel (DECAMP) consortium is a multidisciplinary and translational research program that previously initiated the DECAMP-1 and DECAMP-2 studies for lung cancer early detection. Now, with the support of Johnson and Johnson, 3 Veterans Administration Hospitals (VAH), 3 Military Treatment Facilities (MTF) and 12 academic hospitals as clinical study sites, several molecular biomarker laboratories, along with Biostatics, Bioinformatics, Pathology and Biorepository cores, we are expanding our work in lung cancer early detection.
Eligibility
Minimum Age: 46 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
University of Alabama, Birmingham, Birmingham, Alabama, United States
University of California Los Angeles, Los Angeles, California, United States
VA Greater LA Healthcare System, Los Angeles, California, United States
Naval Medical Center San Diego, San Diego, California, United States
University of Iowa, Iowa City, Iowa, United States
Walter Reed Army Medical Center, Bethesda, Maryland, United States
VA Boston Healthcare System, Boston, Massachusetts, United States
University of Michigan, Ann Arbor, Michigan, United States
Mayo Clinic, Rochester, Minnesota, United States
Cleveland Clinic, Cleveland, Ohio, United States
American College of Radiology [Administrative Site], Philadelphia, Pennsylvania, United States
University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States
Temple University, Philadelphia, Pennsylvania, United States
University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States
Brown University [Administrative Site], Providence, Rhode Island, United States
VA Tennessee Valley Healthcare System, Nashville, Tennessee, United States
MD Anderson Cancer Center [Administrative Site], Houston, Texas, United States
Naval Medical Center Portsmouth, Portsmouth, Virginia, United States
West Virginia University, Morgantown, West Virginia, United States
Contact Details
Name: Ehab Billatos, MD
Affiliation: Boston University
Role: PRINCIPAL_INVESTIGATOR
Name: Denise Aberle, MD
Affiliation: University of California, Los Angeles
Role: PRINCIPAL_INVESTIGATOR
Name: George Washko, MD
Affiliation: Brigham and Women's Hospital
Role: PRINCIPAL_INVESTIGATOR
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