Spots Global Cancer Trial Database for DECAMP-2: Screening of Patients With Early Stage Lung Cancer or at High Risk for Developing Lung Cancer
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Trial Identification
Brief Title: DECAMP-2: Screening of Patients With Early Stage Lung Cancer or at High Risk for Developing Lung Cancer
Official Title: Detection of Early Lung Cancer Among Military Personnel Study 2 (DECAMP-2): Screening of Patients With Early Stage Lung Cancer or at High Risk for Developing Lung Cancer
Study ID: NCT02504697
Conditions
Interventions
Study Description
Brief Summary: The goal of this project is to improve lung cancer screening in high-risk individuals by identifying biomarkers of preclinical disease and disease risk that are measured in minimally invasive and non-invasive biospecimens. Existing biomarkers for lung cancer diagnosis as well as new biomarkers discovered specifically in this clinical setting will be examined. Biomarkers that identify individuals at highest risk for being diagnosed with lung cancer prior to the appearance of concerning symptoms could increase the utility of lung cancer surveillance and the efficiency of lung cancer chemoprevention clinical trials. Achieving these goals would improve the detection and treatment of early stage and incipient lung cancer, while restricting the risk of these procedures to those individuals who currently exhibit the early molecular warning signs of impending disease.
Detailed Description: The Detection of Early lung Cancer Among Military Personnel (DECAMP) consortium is a multidisciplinary and translational research program that includes 7 Veterans Administration Hospitals (VAH), the 4 designated Military Treatment Facilities (MTF) and 4 academic hospitals as clinical study sites, several molecular biomarker laboratories, along with Biostatics, Bioinformatics, Pathology and Biorepository cores. The DECAMP Coordinating Center will facilitate rapid selection, design and execution of clinical studies within this multi-institutional consortium. The ACRIN 4704 study will recruit one cohort to achieve the aims of this study: a longitudinal screening cohort.
Keywords
Eligibility
Minimum Age: 50 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: Yes
Locations
Regents of the University of California LA (Los Angeles VA Healthcare System), Los Angeles, California, United States
University of California Los Angeles Medical Center, Los Angeles, California, United States
Naval Medical Center San Diego, San Diego, California, United States
Denver Research Institute, Denver, Colorado, United States
Walter Reed National Military Medical Center, Bethesda, Maryland, United States
Boston University Medical Center, Boston, Massachusetts, United States
Boston VA Research Institute, Inc, Boston, Massachusetts, United States
Health Research Inc. Roswell Park Division, Buffalo, New York, United States
Trustees of University of Pennsylvania (Philadelphia VA Medical Center), Philadelphia, Pennsylvania, United States
University of Pennsylvania, Philadelphia, Pennsylvania, United States
Veterans Research Foundation of Pittsburgh, Pittsburgh, Pennsylvania, United States
Middle Tennessee Research Institute (Vanderbilt University), Nashville, Tennessee, United States
Dallas VA Research Corporation, Dallas, Texas, United States
San Antonio Military Medical Center, San Antonio, Texas, United States
Naval Medical Center Portsmouth, Portsmouth, Virginia, United States
Contact Details
Name: Ehab Billatos, MD
Affiliation: Boston University
Role: PRINCIPAL_INVESTIGATOR
Name: Denise Aberle, MD
Affiliation: University of California, Los Angeles
Role: PRINCIPAL_INVESTIGATOR
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