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Spots Global Cancer Trial Database for Screening for Coronary Artery Disease After Mediastinal Irradiation

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Trial Identification

Brief Title: Screening for Coronary Artery Disease After Mediastinal Irradiation

Official Title: Screening for Coronary Artery Disease After Mediastinal Irradiation in Hodgkin Lymphoma Survivors

Study ID: NCT01271127

Study Description

Brief Summary: Survivors of Hodgkin Lymphoma (HL) are known to have an increased risk of developing late treatment sequelae such as cardiovascular events due to coronary artery disease. At present no active screening is performed in these patients since it is not known whether screening and subsequent treatment by means of revascularization is effective in reducing the risk of cardiovascular events in symptomatic individuals. In the trial the efficacy and therapeutic consequences of screening for coronary artery diasease by multi-slice CT (MSCT) among asymptomatic HL survivors will be evaluated.

Detailed Description: Objectives: 1. to determine whether MSCT as a screening method of HL survivors treated with mediastinal irradiation accurately identifies asymptomatic significant coronary artery disease. 2. to establish the prevelance of coronary abnormalities in HL survivors treated with mediastinal irradiation 3. to determine the frequency and type of intervention 4. to evaluate the acceptance of screening and asses quality of life among Hl survivors. Study polulation: 50 long term survivors of HL, previously treatef with mediastinal irradiation without present evidence of cardiovascular disease Intervention: CT-coronary angiography and calcium score, to be performed as a screening method (to indicate further diagnostic treatent procedures)

Eligibility

Minimum Age: 35 Years

Eligible Ages: ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Leiden University Medical Center, Leiden, Zuid-Holland, Netherlands

Contact Details

Name: A.D.G. KRol, MD, PhD

Affiliation: Leiden University Medical Centre

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

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