Spots Global Cancer Trial Database for Prevention of Contrast Induced Nephropathy in Oncology Patients With Sodium Bicarbonate
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Trial Identification
Brief Title: Prevention of Contrast Induced Nephropathy in Oncology Patients With Sodium Bicarbonate
Official Title: Prevention of Contrast Induced Nephropathy in Oncology Patients With Sodium Bicarbonate
Study ID: NCT00540904
Conditions
Study Description
Brief Summary: Contrast induced nephropathy is a rising cause of acute renal failure in all patients. A study published in JAMA 2004, show a superiority of a hydratation with sodium bicarbonate in comparison with the same volume hydratation with sodium bicarbonate. The investigators will try following the original protocol making 2 randomized groups of patients, with cancer diagnosis, \>18 years old, with a GFR \<60 and \>30 ml/min/1,73m2 by MDRD formula and/or diabetic patients. In the group 1 the patients will receive a solution with 154 mEq/L of a sodium bicarbonate, 3 cc/Kg/h at 1 hour before the injection of contrast and 1 cc/Kg/h during and 6 hours before the injection. The primary end point will be the rise of 25% or more in creatinine or dialysis needed.
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Hospital do Cancer de Barretos - Fundação PIO XII, Barretos, São Paulo, Brazil
Contact Details
Name: Ricardo G Silva, MD
Affiliation: Hospital do Cancer de Barretos - Fundação PIO XII
Role: PRINCIPAL_INVESTIGATOR
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