Spots Global Cancer Trial Database for NAUTILUS: OKI-179 Plus Binimetinib in Patients With Advanced Solid Tumors in the RAS Pathway (Phase 1b) and NRAS-mutated Melanoma (Phase 2)
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Trial Identification
Brief Title: NAUTILUS: OKI-179 Plus Binimetinib in Patients With Advanced Solid Tumors in the RAS Pathway (Phase 1b) and NRAS-mutated Melanoma (Phase 2)
Official Title: NAUTILUS: A Phase 1b/2 Study of OKI-179 Plus Binimetinib in Patients With Advanced Solid Tumors and Activating Mutations in the RAS Pathway (Phase 1b) and in Patients With Advanced NRAS-Mutated Melanoma (Phase 2)
Study ID: NCT05340621
Interventions
Study Description
Brief Summary: The NAUTILUS study is a Phase 1b/2, multi-center, open-label study in which patients with activating mutations in the RAS pathway (Phase 1b) and patients with NRAS-mutated Melanoma (Phase 2) will be treated with a combination of oral OKI-179 combined with the MEK inhibitor binimetinib.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
CTCA Phoenix, part of City of Hope, Phoenix, Arizona, United States
University of California, San Francisco, San Francisco, California, United States
University of Florida Health Cancer Center, Gainesville, Florida, United States
Emory University Winship Cancer Institute, Atlanta, Georgia, United States
CTCA Atlanta, part of City of Hope, Newnan, Georgia, United States
CTCA Chicago, part of City of Hope, Zion, Illinois, United States
Massachusetts General Hospital, Boston, Massachusetts, United States
Henry Ford Health System, Detroit, Michigan, United States
Memorial Sloan-Kettering Cancer Center, New York, New York, United States
Sarah Cannon Research Institute, Nashville, Tennessee, United States
University of Texas MD Anderson Cancer Center, Houston, Texas, United States
University of Virginia Health System, Charlottesville, Virginia, United States
Contact Details
Name: Ryan Sullivan, MD
Affiliation: Massachusetts General Hospital
Role: PRINCIPAL_INVESTIGATOR
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