Spots Global Cancer Trial Database for Metabolic Changes in Blood Samples From Patients With Acute Myeloid Leukemia
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Trial Identification
Brief Title: Metabolic Changes in Blood Samples From Patients With Acute Myeloid Leukemia
Official Title: A Study of the Metabolic Changes in Leukemia Cells Following Treatment in AML Patients
Study ID: NCT02581917
Study Description
Brief Summary: This research trial studies metabolic changes in blood samples from patients with acute myeloid leukemia. Studying samples of blood from patients with acute myeloid leukemia in the laboratory may help doctors learn more about cancer and the development of drug resistance.
Detailed Description: PRIMARY OBJECTIVES: I. To determine the metabolic adaptations that occur following exposure to standard chemotherapeutic agents using peripheral blood mononuclear cells from acute myeloid leukemia (AML) patients. OUTLINE: Patients undergo collection of peripheral blood mononuclear cell (PBMC) samples for analysis via cell isolation, glycolytic flux and oxygen consumption assays, viability assays, and western blot at baseline, 24, 48, and 72 hours after starting chemotherapy.
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Comprehensive Cancer Center of Wake Forest University, Winston-Salem, North Carolina, United States
Contact Details
Name: Timothy Pardee
Affiliation: Wake Forest University Health Sciences
Role: PRINCIPAL_INVESTIGATOR
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