Spots Global Cancer Trial Database for Gene Analysis in Studying Susceptibility to Wilms Tumor

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Gene Analysis in Studying Susceptibility to Wilms Tumor

Official Title: A Genome-Wide Association Study in Wilms Tumor

Study ID: NCT01808079

Conditions

Recurrent Childhood Kidney Neoplasm

Stage I Kidney Wilms Tumor

Stage II Kidney Wilms Tumor

Stage III Kidney Wilms Tumor

Stage IV Kidney Wilms Tumor

Interventions

Laboratory Biomarker Analysis

Study Description

Brief Summary: This clinical trial studies gene analysis in studying susceptibility to Wilms tumor. Finding genetic markers for Wilms tumor may help identify patients who are at risk of relapse.

Detailed Description: PRIMARY OBJECTIVES: I. To use a genome-wide association analysis to identify novel genetic variants that confer susceptibility to Wilms tumor. II. To improve our understanding of the genetic architecture and etiology of Wilms tumor. III. To facilitate the identification of genetic markers that are associated with an increased risk of developing of Wilms tumor and/or those at risk of aggressive disease, relapse, additional tumors and/or cancer in their offspring. OUTLINE: Samples are analyzed for single nucleotide polymorphism (SNP) profiling using real-time polymerase chain reaction (PCR) and multiplex ligation-dependent probe amplification (MLPA).