Spots Global Cancer Trial Database for VEGF Trap in Treating Patients With Recurrent or Persistent Endometrial Cancer
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Trial Identification
Brief Title: VEGF Trap in Treating Patients With Recurrent or Persistent Endometrial Cancer
Official Title: A Phase II Evaluation of VEGF-Trap (AFLIBERCEPT, NSC #724770, NCI-Supplied Agent) in the Treatment of Recurrent or Persistent Endometrial Carcinoma
Study ID: NCT00462826
Conditions
Interventions
Study Description
Brief Summary: This phase II trial is studying the side effects and how well VEGF Trap works in treating patients with recurrent or persistent endometrial cancer. VEGF Trap may stop the growth of endometrial cancer by blocking blood flow to the tumor and by carrying tumor-killing substances directly to endometrial cancer cells.
Detailed Description: PRIMARY OBJECTIVES: I. Assess the activity of VEGF Trap in patients with recurrent or persistent endometrial cancer, in terms of the frequency of patients who have progression-free survival for at least 6 months after initiating therapy or have objective tumor response. II. Determine the toxicity of this drug in these patients. SECONDARY OBJECTIVES: I. Determine the duration of progression-free survival and overall survival of patients treated with this drug. OUTLINE: Patients receive VEGF Trap IV over 1 hour on days 1 and 15. Treatment repeats every 28 days in the absence of disease progression or unacceptable toxicity. After completion of study treatment, patients are followed every 3 months for 2 years and then every 6 months for 3 years.
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: FEMALE
Healthy Volunteers: No
Locations
Hartford Hospital, Hartford, Connecticut, United States
The Hospital of Central Connecticut, New Britain, Connecticut, United States
Washington Hospital Center, Washington, District of Columbia, United States
Jupiter Medical Center, Jupiter, Florida, United States
Florida Hospital, Orlando, Florida, United States
Memorial Health University Medical Center, Savannah, Georgia, United States
Northwestern University, Chicago, Illinois, United States
University of Illinois, Chicago, Illinois, United States
University of Chicago, Chicago, Illinois, United States
Saint Vincent Hospital and Health Services, Indianapolis, Indiana, United States
University of Iowa Hospitals and Clinics, Iowa City, Iowa, United States
Providence Medical Center, Kansas City, Kansas, United States
Lawrence Memorial Hospital, Lawrence, Kansas, United States
Radiation Oncology Center of Olathe, Olathe, Kansas, United States
Menorah Medical Center, Overland Park, Kansas, United States
Radiation Oncology Practice Corporation Southwest, Overland Park, Kansas, United States
Shawnee Mission Medical Center, Shawnee Mission, Kansas, United States
Franklin Square Hospital Center, Baltimore, Maryland, United States
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland, United States
Massachusetts General Hospital Cancer Center, Boston, Massachusetts, United States
Green Bay Oncology - Escanaba, Escanaba, Michigan, United States
Green Bay Oncology - Iron Mountain, Iron Mountain, Michigan, United States
Centerpoint Medical Center LLC, Independence, Missouri, United States
Truman Medical Center, Kansas City, Missouri, United States
Saint Luke's Cancer Institute, Kansas City, Missouri, United States
Saint Luke's Hospital of Kansas City, Kansas City, Missouri, United States
Radiation Oncology Practice Corporation South, Kansas City, Missouri, United States
Saint Joseph Health Center, Kansas City, Missouri, United States
North Kansas City Hospital, Kansas City, Missouri, United States
Research Medical Center, Kansas City, Missouri, United States
Radiation Oncology Practice Corporation - North, Kansas City, Missouri, United States
Liberty Hospital, Liberty, Missouri, United States
Heartland Regional Medical Center, Saint Joseph, Missouri, United States
Washington University School of Medicine, Saint Louis, Missouri, United States
Cooper Hospital University Medical Center, Camden, New Jersey, United States
Southwest Gynecologic Oncology Associates Inc, Albuquerque, New Mexico, United States
University of New Mexico Cancer Center, Albuquerque, New Mexico, United States
Stony Brook University Medical Center, Stony Brook, New York, United States
Novant Health Presbyterian Medical Center, Charlotte, North Carolina, United States
Gynecologic Oncology Network, Greenville, North Carolina, United States
Wake Forest University Health Sciences, Winston-Salem, North Carolina, United States
Case Western Reserve University, Cleveland, Ohio, United States
MetroHealth Medical Center, Cleveland, Ohio, United States
Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland, Ohio, United States
Cleveland Clinic Foundation, Cleveland, Ohio, United States
Riverside Methodist Hospital, Columbus, Ohio, United States
Mount Carmel Health Center West, Columbus, Ohio, United States
Miami Valley Hospital, Dayton, Ohio, United States
Hillcrest Hospital Cancer Center, Mayfield Heights, Ohio, United States
Lake University Ireland Cancer Center, Mentor, Ohio, United States
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States
Cancer Care Associates-Midtown, Tulsa, Oklahoma, United States
Tulsa Cancer Institute, Tulsa, Oklahoma, United States
Abington Memorial Hospital, Abington, Pennsylvania, United States
Women and Infants Hospital, Providence, Rhode Island, United States
M D Anderson Cancer Center, Houston, Texas, United States
Carilion Clinic Gynecological Oncology, Roanoke, Virginia, United States
Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium, Seattle, Washington, United States
University of Washington Medical Center, Seattle, Washington, United States
Northwest Medical Specialties PLLC, Tacoma, Washington, United States
Green Bay Oncology at Saint Vincent Hospital, Green Bay, Wisconsin, United States
Saint Vincent Hospital, Green Bay, Wisconsin, United States
Green Bay Oncology Limited at Saint Mary's Hospital, Green Bay, Wisconsin, United States
Saint Mary's Hospital, Green Bay, Wisconsin, United States
University of Wisconsin Hospital and Clinics, Madison, Wisconsin, United States
Green Bay Oncology - Oconto Falls, Oconto Falls, Wisconsin, United States
Green Bay Oncology - Sturgeon Bay, Sturgeon Bay, Wisconsin, United States
Contact Details
Name: Robert Coleman
Affiliation: Gynecologic Oncology Group
Role: PRINCIPAL_INVESTIGATOR
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