Spots Global Cancer Trial Database for Cediranib in Combination With Lomustine Chemotherapy in Recurrent Glioblastoma
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Trial Identification
Brief Title: Cediranib in Combination With Lomustine Chemotherapy in Recurrent Glioblastoma
Official Title: A Phase III, Randomised, Parallel Group, Multi-Centre Study in Recurrent Glioblastoma Patients to Compare the Efficacy of Cediranib [RECENTIN™, AZD2171] Monotherapy and the Combination of Cediranib With Lomustine to the Efficacy of Lomustine Alone
Study ID: NCT00777153
Conditions
Study Description
Brief Summary: The purpose of this study is to see how effective cediranib is in treating a brain tumour called recurrent glioblastoma. Two drugs are being tested in this study. Lomustine is an approved oral chemotherapy that belongs to the class of drugs called alkylating agents. Cediranib is a new drug that has not yet been approved for this disease. This study will compare the use of lomustine with cediranib, cediranib alone or lomustine with placebo ("inactive substance") to see whether the combination or cediranib alone will be more effective than the chemotherapy alone (lomustine) in preventing the growth of cancer cells.
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Research Site, Birmingham, Alabama, United States
Research Site, Pheonix, Arizona, United States
Research Site, Los Angeles, California, United States
Research Site, New Haven, Connecticut, United States
Research Site, Gainesville, Florida, United States
Research Site, Jacksonville, Florida, United States
Research Site, Chicago, Illinois, United States
Research Site, Evanston, Illinois, United States
Research Site, Kansas City, Kansas, United States
Research Site, Boston, Massachusetts, United States
Research Site, Detroit, Michigan, United States
Research Site, Amherst, New York, United States
Research Site, New York, New York, United States
Research Site, Cincinnati, Ohio, United States
Research Site, Cleveland, Ohio, United States
Research Site, Columbus, Ohio, United States
Research Site, Philadelphia, Pennsylvania, United States
Research Site, Pittsburgh, Pennsylvania, United States
Research Site, Houston, Texas, United States
Research Site, Seattle, Washington, United States
Research Site, Morgantown, West Virginia, United States
Research Site, Camperdown, , Australia
Research Site, Heidelberg, , Australia
Research Site, Nedlands, , Australia
Research Site, Parkville, , Australia
Research Site, St Leonards, , Australia
Research Site, Woodville, , Australia
Research Site, Graz, , Austria
Research Site, Brussels (Anderlecht), , Belgium
Research Site, Brussels (Jette), , Belgium
Research Site, Brussels (Woluwé-St-Lambert), , Belgium
Research Site, Leuven, , Belgium
Research Site, Calgary, Alberta, Canada
Research Site, Toronto, Ontario, Canada
Research Site, Montreal, Quebec, Canada
Research Site, Liberec, , Czech Republic
Research Site, Bobigny, , France
Research Site, Marseille, , France
Research Site, Paris cedex 13, , France
Research Site, Rennes, , France
Research Site, Saint Herblain, , France
Research Site, Villejuif, , France
Research Site, Berlin, , Germany
Research Site, Bielefeld, , Germany
Research Site, Dresden, , Germany
Research Site, Düsseldorf, , Germany
Research Site, Göttingen, , Germany
Research Site, Hannover, , Germany
Research Site, Heidelberg, , Germany
Research Site, Kiel, , Germany
Research Site, Leipzig, , Germany
Research Site, Nordhausen, , Germany
Research Site, Regensburg, , Germany
Research Site, Amsterdam, , Netherlands
Research Site, Den Haag, , Netherlands
Research Site, Groningen, , Netherlands
Research Site, Maastricht, , Netherlands
Research Site, Rotterdam, , Netherlands
Research Site, Glasgow, , United Kingdom
Research Site, London, , United Kingdom
Research Site, Manchester, , United Kingdom
Research Site, Sutton, , United Kingdom
Contact Details
Name: Jane Robertson
Affiliation: AstraZeneca
Role: STUDY_DIRECTOR
Name: Tracy Batchelor, MD, MPH
Affiliation: Massachusetts General Hospital
Role: PRINCIPAL_INVESTIGATOR
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