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Brief Title: Recurrent High Grade Glioma Treated by LITT
Official Title: Randomized Clinical Trial of Efficiency and Safety of Recurrent High Grade Glioma Treated by Laser Interstitial Thermal Therapy
Study ID: NCT06161610
Brief Summary: This clinical trial aims to investigate the efficiency and safety of laser interstitial thermal therapy (LITT) in recurrent high-grade glioma (rHGG) patients. The main questions it aims to answer are: * The LITT would increase the progression-free survival and overall survival of rHGG patients compared to other treatments. * The LITT is safe and applicable to rHGG patients Participants will be randomized to the intervention group (LITT) or control group at a ratio of 2:1. The intervention group patients will receive LITT. The control group will be treated with any other treatment. The primary outcome of this trial is progression-free survival. The estimated sample size is 135, 90 in the LITT group and 45 in the control group.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Beijing Tiantan Hospital, Beijing, Beijing, China
Beijing Tsinghua Changgung Hospital, Beijing, Beijing, China
The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China
The First Hospital of Jilin University, Changchun, Jilin, China
Qilu Hospital, Jinan, Shandong, China
Huashan Hospital, Shanghai, Shanghai, China
Name: Tao Jiang, MD
Affiliation: Beijing Tiantan Hospital
Role: PRINCIPAL_INVESTIGATOR