Spots Global Cancer Trial Database for Gene Expression Profiles to Categorize Wilms Tumors

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Trial Identification

Brief Title: Gene Expression Profiles to Categorize Wilms Tumors

Official Title: Categorization of Wilms Tumors by Genetic Expression

Study ID: NCT00897637

Conditions

Recurrent Wilms Tumor and Other Childhood Kidney Tumors

Stage I Wilms Tumor

Stage II Wilms Tumor

Stage III Wilms Tumor

Stage IV Wilms Tumor

Stage V Wilms Tumor

Interventions

laboratory biomarker analysis

Study Description

Brief Summary: This laboratory study is using gene expression profiling to identify different categories of Wilms tumors. Studying the genes expressed in samples of tumor tissue from patients with cancer may help doctors identify biomarkers related to cancer.

Detailed Description: OBJECTIVES: I. Identify new molecular categories of Wilms tumor (WT) based on the gene expression profiles of samples from patients with this disease. II. Develop a classifying system (classifier) that will predict a defined number of clinically relevant categories based on expression of an established set of genes. III. Confirm and test the classifier with further analysis of the genes by several different methodologies, using additional patient samples that are outside of the case/cohort but which possess the clinically or scientifically relevant parameter. IV. Validate the use of the classifier to predict defined groups within a second set of samples (for which investigators are blinded to the clinical and biological data) by subsequent comparison with true incidence of pertinent markers. OUTLINE: Three hundred tumor specimens are analyzed for genetic expression profiles using Affymetrix assays. Specific genes are identified as classifiers and analyzed using tissue arrays. An additional 300 specimens are examined for gene expression and categorized according to the classifiers.