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Brief Title: Orelabrutinib in Combination With Thiotepa in Refractory and Relapsed Primary CNS Lymphoma
Official Title: Safety and Efficacy of Orelabrutinib(O) in Combination With Thiotepa(T) in Refractory and Relapsed Primary CNS Lymphoma: A Single-arm, Multicenter Phase Ib/II Study(OT)
Study ID: NCT05021770
Brief Summary: The purpose of this study was to investigate the maximum tolerated dose and efficacy of Orelabrutinib combined with Thiotepa in refractory and relapsed primary central nervous system lymphoma (PCNSL).
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China