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Spots Global Cancer Trial Database for Pilot Study of Elemene in Treating Patients With Refractory Glioblastoma

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Trial Identification

Brief Title: Pilot Study of Elemene in Treating Patients With Refractory Glioblastoma

Official Title: A Pilot Study of Elemene Injectable Emulsion in Treating Patients With Refractory Glioblastoma

Study ID: NCT04674527

Interventions

Elemene
Temozolomide

Study Description

Brief Summary: This is a pilot phase I study to evaluate the safety and efficacy on elemene injectable emulsion in treating patients with glioblastoma. Elemene, isolated from the Chinese medicinal herb Curcuma wenyujin, was shown to exhibit antitumor activity in human and murine tumor cells in vitro and in vivo.Elemene injectable emulsion against malignant tumors was low. Therefore, the effect of Elemene injectable emulsion being used in clinical settings needs to be confirmed by further RCTs.

Detailed Description: Background * Elemene, isolated from the Chinese medicinal herb Curcuma wenyujin, was shown to exhibit antitumor activity in human and murine tumor cells in vitro and in vivo * The study shows that the methodological quality of RCTs of Elemene injectable emulsion against malignant tumors was low. Therefore, the effect of Elemene injectable emulsion being used in clinical settings needs to be confirmed by further RCTs Objectives * To evaluate the safety of Elemene injectable emulsion to treat Refractory Glioblastoma with TMZ * To evaluate the efficacy of Elemene injectable emulsion to treat Refractory Glioblastoma with TMZ Design This clinical trail is a randomized controlled trial.In control group,patients will receive TMZ-chemotherapy.In experimental group,patients will receive elemene injectable emulsion and TMZ-chemotherapy at the same time.

Keywords

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China

Contact Details

Name: Jianmin Zhang, MD

Affiliation: Second Affiliated Hospital, School of Medicine, Zhejiang University

Role: STUDY_CHAIR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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