Spots Global Cancer Trial Database for BAFFR-targeting CAR T Cells for Patients With Relapsed or Refractory B-NHL
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Trial Identification
Brief Title: BAFFR-targeting CAR T Cells for Patients With Relapsed or Refractory B-NHL
Official Title: A Phase 1 Study Evaluating BAFFR-targeting CAR T Cells for Patients With Relapsed or Refractory B-cell Non-Hodgkin's Lymphoma (B-NHL)
Study ID: NCT05370430
Interventions
Study Description
Brief Summary: A Phase 1 Study Evaluating BAFFR-targeting CAR T Cells for Patients with Relapsed or Refractory B-cell Non-Hodgkin's Lymphoma (B-NHL)
Detailed Description: This phase I trial evaluates the side effects and best dose of BAFFR-CAR T cells in treating patients with B-cell Non-Hodgkin's Lymphoma (B-NHL) that has come back (recurrent) or does not respond to treatment (refractory). T cells are infection fighting blood cells that can kill cancer cells. The T cells given in this study will come from the patient and will have a new gene put in them that makes them able to recognize BAFFR, a protein on the surface of cancer cells. These BAFFR-specific T cells may help the body's immune system identify and kill BAFFR+ cancer cells.
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
City of Hope Medical Center, Duarte, California, United States
Contact Details
Name: Elizabeth Budde, MD
Affiliation: City of Hope Medical Center
Role: PRINCIPAL_INVESTIGATOR
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