Spots Global Cancer Trial Database for A Study to Evaluate Mezigdomide in Combination With Carfilzomib and Dexamethasone (MeziKD) Versus Carfilzomib and Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma (SUCCESSOR-2)
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Trial Identification
Brief Title: A Study to Evaluate Mezigdomide in Combination With Carfilzomib and Dexamethasone (MeziKD) Versus Carfilzomib and Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma (SUCCESSOR-2)
Official Title: A Phase 3, Two-stage, Randomized, Multicenter, Open-label Study Comparing Mezigdomide (CC-92480/BMS-986348), Carfilzomib, and Dexamethasone (MeziKD) Versus Carfilzomib and Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM): SUCCESSOR-2
Study ID: NCT05552976
Conditions
Study Description
Brief Summary: The purpose of the study is to compare Mezigdomide (CC-92480/BMS-986348) with carfilzomib and dexamethasone (MeziKD) against carfilzomib and dexamethasone (Kd) in the treatment of RRMM: SUCCESSOR-2.
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
USA Mitchell Cancer Institute, Mobile, Alabama, United States
TOI Clinical Research, Cerritos, California, United States
Kaiser Permanente - Irvine, Irvine, California, United States
Los Angeles Hematology Oncology Medical Group, Los Angeles, California, United States
Local Institution - 0279, Newark, Delaware, United States
Winship Cancer Institute, Emory University, Atlanta, Georgia, United States
Saint Alphonsus Regional Medical Center, Boise, Idaho, United States
Local Institution - 0289, Annapolis, Maryland, United States
Dana-Farber Cancer Institute, Boston, Massachusetts, United States
Regional Cancer Care Associates, Little Silver, New Jersey, United States
Montefiore Medical Center, Bronx, New York, United States
University of North Carolina Medical Center, Chapel Hill, North Carolina, United States
Riverside Methodist Hospital, Columbus, Ohio, United States
Charleston Oncology, P.A., Charleston, South Carolina, United States
Houston Methodist Hospital, Houston, Texas, United States
Baylor Scott & White Medical Center - Temple, Temple, Texas, United States
Northwest Medical Specialties PLLC, Tacoma, Washington, United States
WVU Cancer Institute, Morgantown, West Virginia, United States
Instituto Alexander Fleming, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina
Hospital Italiano de Buenos Aires, ABB, Ciudad Autónoma De Buenos Aires, Argentina
Fundacion Estudios Clinicos, Rosario, Santa Fe, Argentina
Local Institution - 0319, San Miguel de Tucumán, Tucumán, Argentina
Local Institution - 0150, Buenos Aires, , Argentina
Sanatorio Allende - Nueva Córdoba, Córdoba, , Argentina
Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
Gosford Hospital, Gosford, New South Wales, Australia
Port Macquarie - Mid North Coast Cancer Institute, Port Macquarie, New South Wales, Australia
Royal North Shore Hospital, St Leonards, New South Wales, Australia
St Vincent's Hospital, Sydney, New South Wales, Australia
Royal Adelaide Hospital, Adelaide, South Australia, Australia
Local Institution - 0229, Hobart, Tasmania, Australia
Bendigo Health Care Group, Bendigo, Victoria, Australia
Epworth Freemasons, East Melbourne, Victoria, Australia
Austin Health, Heidelberg, Victoria, Australia
St Vincent's Hospital, Melbourne, Victoria, Australia
Local Institution - 0266, Vienna, Wien, Austria
Ordensklinikum Linz GmbH Elisabethinen, Linz, , Austria
Medizinische Universität Wien, Wien, , Austria
Local Institution - 0119, Wien, , Austria
Instituto D'Or de Pesquisa e Ensino (IDOR) - Filial Salvador, Salvador, Bahia, Brazil
Hospital do Câncer Mãe de Deus, Porto Alegre, Rio Grande Do Sul, Brazil
A. C. Camargo Cancer Center, Sao Paulo, São Paulo, Brazil
Instituto de Educação, Pesquisa e Gestão em Saúde, Rio de Janeiro, , Brazil
Local Institution - 0086, Rio de Janeiro, , Brazil
Clínica Médica São Germano S/S Ltda, São Paulo, , Brazil
Local Institution - 0304, Sofia, Sofia (stolitsa), Bulgaria
Local Institution - 0305, Plovdiv, , Bulgaria
Local Institution - 0309, Sofia, , Bulgaria
QEII Health Sciences Centre - Victoria General Site, Halifax, Nova Scotia, Canada
Victoria Hospital & Children's Hospital - London Health Sciences Centre, London, Ontario, Canada
Princess Margaret Cancer Centre, Toronto, Ontario, Canada
Local Institution - 0186, Montreal, Quebec, Canada
Local Institution - 0318, Hefei, Anhui, China
Beijing Chaoyang Hospital, Capital Medical University, Beijing City, Beijing, China
Beijing Chaoyang Hospital, Capital Medical University, Beijing, Beijing, China
Beijing Peking Union Medical College Hospital, Beijing, Beijing, China
Local Institution - 0123, Fuzhou, Fujian, China
Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China
Local Institution - 0315, Guangzhou, Guangdong, China
Local Institution - 0051, Zhengzhou, Henan, China
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
Local Institution - 0054, Wuhan, Hubei, China
Local Institution - 0103, Changsha, Hunan, China
The Third Xiangya Hospital of Central South University, Changsha, Hunan, China
Zhongda Hospital Southeast University, Nanjing, Jiangsu, China
Affiliated Hospital of Nantong University, Nantong, Jiangsu, China
The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China
Wuxi People's Hospital, Wuxi, Jiangsu, China
The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China
The First Hospital of Jilin University, Changchun, Jilin, China
The First Hospital of China Medical University, Shenyang, Liaoning, China
Shengjing Hospital of China Medical University, Shenyang, Liaoning, China
Xi'an International Medical Center Hospital, Xi'an, Shaanxi, China
Qilu Hospital of Shandong University (Qingdao), Jinan, Shandong, China
Local Institution - 0118, Shanghai, Shanghai, China
Local Institution - 0317, Shanghai, Shanghai, China
Tianjin Medical University Cancer Institute And Hospital, Tianjing, Tianjin, China
Local Institution - 0058, Kunming, Yunnan, China
The first Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
Local Institution - 0115, Wenzhou, Zhejiang, China
Local Institution - 0059, Taiyuan, , China
Hospital Pablo Tobon Uribe, Medellin, Antioquia, Colombia
Sociedad De Oncologia Y Hematologia Del Cesar, Valledupar, Cesar, Colombia
Local Institution - 0154, Bogota, Cundinamarca, Colombia
IPS Centro Médico Julián Coronel S.A.S, Cali, Valle Del Cauca, Colombia
Aarhus Universitetshospital, Skejby, Aarhus, Midtjylland, Denmark
Roskilde Sygehus, Roskilde, Sjælland, Denmark
Odense Universitetshospital, Odense, Syddanmark, Denmark
Local Institution - 0125, Vejle, Syddanmark, Denmark
Universitaetsklinikum Schleswig-Holstein Campus Kiel, Kiel, Schleswig-Holstein, Germany
Local Institution - 0007, Berlin, , Germany
Universitaetsklinikum Heidelberg, Heidelberg, , Germany
Local Institution - 0102, Köln, , Germany
Universitätsklinikum Leipzig, Leipzig, , Germany
Local Institution - 0133, Nürnberg, , Germany
Local Institution - 0124, Ulm, , Germany
Local Institution - 0014, Wuerzburg, , Germany
University Hospital of Patras, Patras, Achaḯa, Greece
Alexandra General Hospital of Athens, Athens, Attikí, Greece
Local Institution - 0134, Thessaloniki, Thessaloníki, Greece
Queen Mary Hospital, Hksar, , Hong Kong
Local Institution - 0036, Pécs, Baranya, Hungary
Debreceni Egyetem Klinikai Kozpont, Debrecen, Hajdú-Bihar, Hungary
Szabolcs-Szatmár-Bereg Megyei Kórházak és Egyetemi Oktatókórház, Jósa András Oktatókórház, Nyiregyhaza, Szabolcs-Szatmár-Bereg, Hungary
Semmelweis Egyetem, Budapest, , Hungary
Del-pesti Centrumkorhaz - Orszagos Hematologiai es Infektologiai Intezet, Budapest, , Hungary
Local Institution - 0310, Hyderabad, Andhra Pradesh, India
Rajiv Gandhi Cancer Institute And Research Centre, New Delhi, Delhi, India
Medanta-The Medicity, Gurgaon, Haryana, India
HCG-Bangalore, Bengaluru, Karnataka, India
Local Institution - 0168, Mumbai, Maharashtra, India
Mumbai Oncocare Centre - Thane, Thane, Maharashtra, India
Max Super Specialty Hospital - Mohali, Mohali, Punjab, India
Local Institution - 0174, Chennai, Tamil Nadu, India
Apollo Institute of Medical Sciences and Research, Hyderabad, Telangana, India
Yashoda Hospitals - Hitech City, Hyderabad, Telangana, India
Local Institution - 0230, Chandigarh, , India
Edith Wolfson Medical Center, Holon, HaMerkaz, Israel
Hadassah Medical Center, Jerusalem, , Israel
Yitzhak Shamir Medical Center, Zerifin, , Israel
IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Emilia-Romagna, Italy
Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milano, Lombardia, Italy
Humanitas, Rozzano, Milano, Italy
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola, Bologna, , Italy
Azienda Ospedaliera "Pugliese Ciaccio", Catanzaro, , Italy
Ospedale Vito Fazzi, Lecce, , Italy
Azienda Ospedaliera Universitaria Pisana, Pisa, , Italy
P.O. "S. Maria della Misericordia" Azienda Sanitaria Universitaria Friuli Centrale, Udine, , Italy
Nagoya City University Hospital, Nagoya, Aichi, Japan
National Cancer Center Hospital East, Kashiwa, Chiba, Japan
Japan Community Healthcare Organization Kyushu Hospital, Kitakyushu-shi, Fukuoka, Japan
National Hospital Organization Hokkaido Cancer Center, Sapporo, Hokkaido, Japan
Mito Medical Center, Higashiibaraki, Ibaraki, Japan
Local Institution - 0300, Kanazawa, Ishikawa, Japan
Local Institution - 0209, Shiwa-gun Yahaba-cho, Iwate, Japan
Local Institution - 0234, Kamakura, Kanagawa, Japan
Local Institution - 0225, Koshigaya, Saitama, Japan
Local Institution - 0236, Itabashiku, Tokyo, Japan
Japanese Foundation for Cancer Research, Koto, Tokyo, Japan
Local Institution - 0303, Chuo, Yamanashi, Japan
Chiba University Hospital, Chiba, , Japan
Local Institution - 0226, Fukuoka, , Japan
Japanese Red Cross Fukuoka Hospital, Fukuoka, , Japan
Kumamoto University, Kumamoto, , Japan
University Hospital,Kyoto Prefectural University of Medicine, Kyoto, , Japan
Local Institution - 0213, Nagasaki, , Japan
National Hospital Organization Okayama Medical Center, Okayama, , Japan
Local Institution - 0301, Osaka, , Japan
Local Institution - 0241, Tokyo, , Japan
Japanese Red Cross Medical Center, Tokyo, , Japan
Seoul National University Hospital, Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of
Local Institution - 0239, Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of
The Catholic Univ. of Korea Seoul St. Mary's Hospital, Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of
Local Institution - 0113, Breda, Noord-Brabant, Netherlands
Local Institution - 0194, Enschede, , Netherlands
Haukeland Universitetssjukehus, Bergen, Hordaland, Norway
Stavanger Universitetssykehus, Stavanger, Rogaland, Norway
Oslo Universitetssykehus Ullevål, Oslo, , Norway
Local Institution - 0316, San Juan, , Puerto Rico
Local Institution - 0284, Brasov, Brașov, Romania
Local Institution - 0282, Bucuresti, București, Romania
Local Institution - 0290, Timișoara, Timiș, Romania
Local Institution - 0302, București, , Romania
Local Institution - 0287, București, , Romania
Local Institution - 0306, Sibiu, , Romania
National University Hospital, Singapore, Central Singapore, Singapore
Singapore General Hospital, Singapore, Central Singapore, Singapore
Institut Català d'Oncologia (ICO) - Badalona, Badalona, Barcelona [Barcelona], Spain
Hospital Universitari Vall d'Hebron, Barcelona, Barcelona [Barcelona], Spain
Institut Català d'Oncologia - L'Hospitalet, L'Hospitalet Del Llobregat, Barcelona [Barcelona], Spain
Local Institution - 0108, Majadahonda, Madrid, Comunidad De, Spain
Hospital Universitario de Canarias, San Cristobal de La laguna, Santa Cruz De Tenerife, Spain
Local Institution - 0192, San Cristobal de La laguna, Santa Cruz De Tenerife, Spain
Local Institution - 0037, Valencia, Valenciana, Comunitat, Spain
Hospital Universitario Virgen Nieves, Granada, , Spain
Hospital General Universitario Gregorio Marañon, Madrid, , Spain
Hospital Universitario La Paz, Madrid, , Spain
H.R.U Málaga - Hospital General, Málaga, , Spain
Chang Gung Memorial Hospital- Chiayi, Chiayi City, Chiayi, Taiwan
Chang Gung Memorial Hospital at Kaohsiung, Kaohsiung Niao Sung Dist, Kaohsiung, Taiwan
E-Da Cancer Hospital, Kaohsiung, , Taiwan
Taichung Veterans General Hospital, Taichung, , Taiwan
Local Institution - 0002, Tainan, , Taiwan
Local Institution - 0149, Taipei, , Taiwan
Taipei Veterans General Hospital, Taipei, , Taiwan
Derriford Hospital, Plymouth, Devon, United Kingdom
Norfolk and Norwich University Hospitals NHS Foundation Trust, Cringleford, England, United Kingdom
Local Institution - 0039, Birmingham, , United Kingdom
Local Institution - 0273, Birmingham, , United Kingdom
The Beatson West of Scotland Cancer Centre, Glasgow, , United Kingdom
St James's University Hospital, Leeds, , United Kingdom
Musgrove Park Hospital, Taunton, , United Kingdom
Contact Details
Name: Bristol-Myers Squibb
Affiliation: Bristol-Myers Squibb
Role: STUDY_DIRECTOR
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