Spots Global Cancer Trial Database for A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)
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Trial Identification
Brief Title: A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)
Official Title: A Phase 3, Two-Stage, Randomized, Multicenter, Open-Label Study Comparing Mezigdomide (CC-92480), Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Subjects With Relapsed or Refractory Multiple Myeloma (RRMM): SUCCESSOR-1
Study ID: NCT05519085
Conditions
Study Description
Brief Summary: The purpose of this study is to compare the efficacy and safety of mezigdomide (CC-92480), bortezomib and dexamethasone (MeziVd) versus pomalidomide, bortezomib and dexamethasone (PVd) in participants with relapsed or refractory multiple myeloma (RRMM) who received between 1 to 3 prior lines of therapy and who have had prior lenalidomide exposure.
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Local Institution - 0366, Los Alamitos, California, United States
Local Institution - 0272, San Diego, California, United States
Private Practice - Dr. James R. Berenson, West Hollywood, California, United States
Advanced Research, Tamarac, Florida, United States
University Cancer Blood Ctr, Athens, Georgia, United States
Local Institution - 0048, Marietta, Georgia, United States
Central Care Cancer Center - Garden City, Garden City, Kansas, United States
University of Kansas Medical Center, Kansas City, Kansas, United States
Local Institution - 0358, Baton Rouge, Louisiana, United States
Tulane Cancer Center, New Orleans, Louisiana, United States
Local Institution - 0357, Baltimore, Maryland, United States
Local Institution - 0246, Boston, Massachusetts, United States
University of Michigan, Ann Arbor, Michigan, United States
Hattiesburg Clinic Hematology/Oncology, Hattiesburg, Mississippi, United States
Local Institution - 0242, Jackson, Mississippi, United States
Astera Cancer Care, East Brunswick, New Jersey, United States
Local Institution - 0363, Ridgewood, New Jersey, United States
University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico, United States
Local Institution - 0245, Buffalo, New York, United States
Northwell Health/ RJ Zuckerberg Cancer Center, Lake Success, New York, United States
Rochester General Hospital, Rochester, New York, United States
Local Institution - 0274, Williamsville, New York, United States
Duke Cancer Institute, Durham, North Carolina, United States
Cleveland Clinic, Cleveland, Ohio, United States
Local Institution - 0359, Allentown, Pennsylvania, United States
Local Institution - 0264, York, Pennsylvania, United States
The West Clinic, PLLC dba West Cancer Center, Germantown, Tennessee, United States
University of Texas MD Anderson Cancer Center, Houston, Texas, United States
Mays Cancer Center, San Antonio, Texas, United States
Utah Cancer Specialists, Salt Lake City, Utah, United States
Hematology Oncology Associates of Fredericksburg, Fredericksburg, Virginia, United States
VA Puget Sound Health Care System, Seattle, Washington, United States
Local Institution - 0293, Seattle, Washington, United States
Local Institution - 0097, Spokane, Washington, United States
Local Institution - 0220, Madison, Wisconsin, United States
Sanatorio Chivilcoy, Chivilcoy, Buenos Aires, Argentina
Hospital Privado Universitario de Córdoba, Cordoba, Córdoba, Argentina
Clinica Viedma S. A, Viedma, Río Negro, Argentina
Hospital Privado de Rosario, Rosario, Santa Fe, Argentina
Centro Mdico "Barrio Parque", Buenos Aires, , Argentina
Hospital Británico de Buenos Aires, Buenos Aires, , Argentina
Clínica de Nefrología, Urología y Enfermedades Cardiovasculares, Santa Fe, , Argentina
Liverpool Hospital, Liverpool, New South Wales, Australia
Calvary Mater Newcastle, Waratah, New South Wales, Australia
Wollongong Hospital-Illawarra Cancer Care Centre, Wollongong, New South Wales, Australia
Sunshine Coast University Hospital, Birtinya, Queensland, Australia
Box Hill Hospital, Box Hill, Victoria, Australia
The Alfred Hospital, Melbourne, Victoria, Australia
St Vincent's Hospital, Melbourne, Victoria, Australia
Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
Klinik Ottakring, Vienna, Wien, Austria
Universitätsklinikum Krems, Krems an der Donau, , Austria
LKH Hochsteiermark - Standort Leoben, Leoben, , Austria
Universitätsklinikum St. Pölten, St. Pölten, , Austria
Hanusch-Krankenhaus, Wien, , Austria
Ziekenhuis Oost-Limburg, Campus St.-Jan, Genk, Limburg, Belgium
UZ Gent, Gent, Oost-Vlaanderen, Belgium
AZ Nikolaas, Sint-Niklaas, Oost-Vlaanderen, Belgium
ZNA Cadix, Antwerpen, , Belgium
Instituto D'Or de Pesquisa e Ensino (IDOR) - Filial Salvador, Salvador, Bahia, Brazil
Centro Gaucho Integrado De Oncologia, Hematologia, Ensino E Pesquisa, Porto Alegre, Rio Grande Do Sul, Brazil
Instituto Joinvilense de Hematologia e Oncologia, Joinville, Santa Catarina, Brazil
Hospital Amaral Carvalho, Jaú, São Paulo, Brazil
Americas Centro de Oncologia Integrado, Rio de Janeiro, , Brazil
Clínica Médica São Germano S/S Ltda, Sao Paulo, , Brazil
Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein, Sao Paulo, , Brazil
Centre Intégré de Santé et de Services Sociaux de la Montérégie-Centre, Greenfield Park, Quebec, Canada
Centre intégré universitaire de santé et de services sociaux du Nord-de-l'Île-de-Montréal (CIUSSS NÎM) - Hôpital du Sacré-Coeur, Montreal, Quebec, Canada
Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus, Quebec City, Quebec, Canada
Clínica Inmunocel, Santiago, Región Metropolitana De Santiago, Chile
Centro de Investigaciones, Viña del Mar, Valparaíso, Chile
Beijing Chaoyang Hospital, Capital Medical University, Beijing City, Beijing, China
Beijing Chaoyang Hospital, Capital Medical University, Beijing City, Beijing, China
Peking University First Hospital, Beijing, Beijing, China
Local Institution - 0141, Beijing, Beijing, China
The First Afffiliated Hospital of Chongqing Medical University, Chongqing, Chongqing, China
The First Affiliated hospital of Xiamen University, Xiamen, Fujian, China
Henan Cancer Hospital, Guangzhou, Guangdong, China
Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China
Local Institution - 0168, Guangzhou, Guangdong, China
Local Institution - 0238, Shenzhen, Guangdong, China
Guangxi Medical University No.1 Affiliated Hospital, Nanning, Guangxi, China
The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China
People's Hospital of Henan Province, Zhengzhou, Henan, China
Wuhan Union Hospital, Wuhan, Hubei, China
Xiangya Hospital Central South University, Changsha, Hunan, China
The Third Xiangya Hospital of Central South University, Changsha, Hunan, China
Local Institution - 0111, Nanjing, Jiangsu, China
Wuxi People's Hospital, Wuxi, Jiangsu, China
Shengjing Hospital of China Medical University, Shenyang, Liaoning, China
The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'An, Shaanxi, China
Local Institution - 0110, Xi'an, Shaanxi, China
The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China
Shanghai 6th people's hospital, Shanghai, Shanghai, China
Local Institution - 0350, Shanghai, Shanghai, China
First Affiliated Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
Local Institution - 0356, Deyang, Sichuan, China
Tianjin Medical University Cancer Institute and Hospital, Tianjin, Tianjin, China
Local Institution - 0353, Urumqi, Xinjiang, China
First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China
Local Institution - 0151, Hangzhou, Zhejiang, China
Local Institution - 0348, Linhai, Zhejiang, China
Ningbo First Hospital, Ningbo, Zhejiang, China
The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
Shanxi Bethune Hospital, Taiyuan, , China
Fakultní nemocnice Brno Bohunice, Brno, Brno-město, Czechia
Vseobecna fakultni nemocnice v Praze, Praha, , Czechia
Kuopion Yliopistollinen Sairaala, Kuopio, Pohjois-Savo, Finland
Helsinki University Hospital - Comprehensive Cancer Center (HYKS - Syöpäkeskus), Helsinki, , Finland
Institut de cancérologie Strasbourg Europe (ICANS), Strasbourg, Alsace, France
CHU Bordeaux Haut-Leveque, Pessac, Aquitaine, France
Centre Hospitalier Universitaire de Nîmes - Institut de Cancérologie du Gard - Hôpital Universitaire Carémeau, Nîmes, Gard, France
Hopital Claude Huriez - CHU de Lille, Lille, Nord, France
Centre Leon Berard, Lyon Cedex08, Rhône-Alpes, France
Centre Hospitalier Universitaire Estaing, Clermont-Ferrand, , France
Centre Hospitalier Universitaire de Limoges - Hôpital Dupuytren, Limoges, , France
Centre Hospitalier Universitaire de Nantes - L' Hopital l'hôtel-Dieu, Nantes, , France
Centre Hospitalier Régional Universitaire de Tours - Hôpital Bretonneau, Tours, , France
Hôpital Saint Antoine, Paris, Île-de-France, France
Universitätsklinikum Marburg, Marburg, Hessen, Germany
Universitätsklinikum Bonn, Bonn, Nordrhein-Westfalen, Germany
Universitaetsklinikum Schleswig-Holstein Campus Kiel, Kiel, Schleswig-Holstein, Germany
Universitaetsklinikum Hamburg-Eppendorf, Hamburg, , Germany
Universitaetsklinikum Tuebingen, Tuebingen, , Germany
Evangelismos General Hospital of Athens, Athens, Attikí, Greece
Alexandra General Hospital of Athens, Athens, Attikí, Greece
G. Papanikolaou General Hospital, Thessaloniki, Thessaloníki, Greece
Local Institution - 0342, Ahmedabad, Gujarat, India
Local Institution - 0338, Gurugram, Haryana, India
Local Institution - 0336, Belagavi, Karnataka, India
Local Institution - 0344, Madurai, Tamil Nadu, India
Local Institution - 0341, Varanasi, Uttar Pradesh, India
Local Institution - 0343, Ludhiana, , India
Local Institution - 0345, Puducherry, , India
University College Hospital - Galway, Galway, Connaught, Ireland
Cork University Hospital, Cork, , Ireland
St. James's Hospital, Dublin, , Ireland
Meir Medical Center, Kfar Saba, HaMerkaz, Israel
Sheba Medical Center, Ramat Gan, HaMerkaz, Israel
Rambam Health Care Campus, Haifa, HaTsafon, Israel
Sourasky Medical Center, Tel Aviv, Tall Abīb, Israel
Hadassah Medical Center - Do Not Use - Duplicate Facility, Jerusalem, Yerushalayim, Israel
Rabin Medical Center, Peatch Tikva, , Israel
Policlinico "G. Rodolico", Catania, Sicilia, Italy
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola, Bologna, , Italy
Fondazione IRCCS Policlinico San Matteo, Pavia, , Italy
Azienda Ospedaliera Sant'Andrea, Roma, , Italy
Local Institution - 0281, Kashiwa, Chiba, Japan
Japan Community Healthcare Organization Kyushu Hospital, Kitakyushu-shi, Fukuoka, Japan
National Hospital Organization Hokkaido Cancer Center, Sapporo, Hokkaido, Japan
Iwate Medical University Hospital, Shiwa-gun Yahaba-cho, Iwate, Japan
Shonan Kamakura General Hospital, Kamakura, Kanagawa, Japan
Saitama Medical University Hospital, Iruma, Saitama, Japan
Dokkyo Medical University Saitama Medical Center, Koshigaya, Saitama, Japan
Shizuoka Cancer Center, Nagaizumi-cho,Sunto-gun, Shizuoka, Japan
Nihon University Itabashi Hospital, Itabashiku, Tokyo, Japan
Chiba University Hospital, Chiba, , Japan
National Hospital Organization Kyushu Medical Center, Fukuoka, , Japan
Japanese Red Cross Fukuoka Hospital, Fukuoka, , Japan
Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital, Hiroshima, , Japan
Kumamoto University, Kumamoto, , Japan
The Japanese Red Cross Nagasaki Genbaku Hospital, Nagasaki, , Japan
The Jikei University Hospital, Tokyo, , Japan
Japanese Red Cross Medical Center, Tokyo, , Japan
Local Institution - 0106, Busan, Busan-gwangyeoksi, Korea, Republic of
Pusan National University Hospital, Busan, Busan-gwangyeoksi, Korea, Republic of
Local Institution - 0102, Seongnam, Gyeonggido, Korea, Republic of
Seoul National University Bundang Hospital, Seongnam, Gyeonggido, Korea, Republic of
Chonnam National University Hwasun Hospital, Hwasun, Jeonranamdo, Korea, Republic of
Local Institution - 0103, Hwasun, Jeonranamdo, Korea, Republic of
Local Institution - 0101, Seoul, Seoul Teugbyeolsi, Korea, Republic of
Seoul National University Hospital, Seoul, Seoul Teugbyeolsi, Korea, Republic of
Samsung Medical Center, Seoul, Seoul Teugbyeolsi, Korea, Republic of
Local Institution - 0104, Seoul, Seoul Teugbyeolsi, Korea, Republic of
The Catholic Univ. of Korea Seoul St. Mary's Hospital, Seoul, Seoul Teugbyeolsi, Korea, Republic of
Asan Medical Center, Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of
Local Institution - 0105, Seoul, Seoul-teukbyeolsi, Korea, Republic of
Local Institution - 0100, Seoul, , Korea, Republic of
Severance Hospital, Yonsei University Health System, Seoul, , Korea, Republic of
Local Institution, Seoul, , Korea, Republic of
Local Institution - 0335, Tauranga, Bay Of Plenty, New Zealand
Local Institution - 0340, Dunedin, Otago, New Zealand
Local Institution - 0334, Auckland, , New Zealand
MICS Centrum Medyczne Torun, Torun, Kujawsko-pomorskie, Poland
Instytut Hematologii i Transfuzjologii, Warsaw, Mazowieckie, Poland
Local Institution - 0325, Kraków, Małopolskie, Poland
Wojewódzki Szpital Specjalistyczny im. J. Korczaka w Słupsku, Słupsk, Pomorskie, Poland
Local Institution - 0346, Skórzewo, Wielkopolskie, Poland
Hospital de Braga, Braga, , Portugal
Champalimaud Foundation, Lisbon, , Portugal
Local Institution - 0301, Porto, , Portugal
Local Institution - 0355, San Juan, , Puerto Rico
Fundeni Clinical Institute, Bucharest, , Romania
Institutul Oncologic Cluj, Cluj Napoca, , Romania
Institutul Regional de Oncologie Iasi, Iasi, , Romania
Hospital Universitari Son Espases, Palma, Balears [Baleares], Spain
Hospital Clínic de Barcelona, Barcelona, Catalunya [Cataluña], Spain
Local Institution - 0073, Barcelona, Catalunya [Cataluña], Spain
Local Institution - 0183, Palma, Illes Balears, Spain
Hospital General Universitario Morales Meseguer, Murcia, Murcia, Región De, Spain
Hospital Costa del Sol, Marbella, Málaga, Spain
Local Institution - 0182, Marbella, Málaga, Spain
Hospital San Pedro de Alcántara, Cáceres, , Spain
Complejo Asistencial Universitario de León - Hospital de León, León, , Spain
Hospital Universitario 12 de Octubre, Madrid, , Spain
Ankara Universitesi Tip Fakultesi Hastanesi, Ankara, , Turkey
Liv Hospital Ankara, Ankara, , Turkey
Istanbul University, Istanbul Faculty of Medicine, Istanbul, , Turkey
Ege Universitesi Hastanesi, İzmir, , Turkey
Erciyes Universitesi Tıp Fakultesi Hastaneleri, Kayseri, , Turkey
Ondokuz Mayıs Universitesi, Samsun, , Turkey
Local Institution - 0326, Cambridge, Cambridgeshire, United Kingdom
The Royal Cornwall Hospital, Truro, England, United Kingdom
Lanarkshire NHS Trust - Monklands Hospital, Airdrie, Great Britain, United Kingdom
King's College Hospital, London, Greater London, United Kingdom
Leicester Royal Infirmary, Leicester, Leicestershire, United Kingdom
Barnet Hospital, Barnet, , United Kingdom
Freeman Hospital, Newcastle upon Tyne, , United Kingdom
Royal Stoke University Hospital, Stoke-on-Trent, , United Kingdom
Contact Details
Name: Bristol-Myers Squibb
Affiliation: Bristol-Myers Squibb
Role: STUDY_DIRECTOR
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