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Spots Global Cancer Trial Database for A Study Comparing Once-weekly vs Twice-weekly Carfilzomib in Combination With Lenalidomide and Dexamethasone in Subjects With Relapsed or Refractory Multiple Myeloma

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Trial Identification

Brief Title: A Study Comparing Once-weekly vs Twice-weekly Carfilzomib in Combination With Lenalidomide and Dexamethasone in Subjects With Relapsed or Refractory Multiple Myeloma

Official Title: A Randomized, Open-label, Phase 3 Study Comparing Once-weekly vs Twice-weekly Carfilzomib in Combination With Lenalidomide and Dexamethasone in Subjects With Relapsed or Refractory Multiple Myeloma (A.R.R.O.W.2)

Study ID: NCT03859427

Study Description

Brief Summary: Compare efficacy of 56 mg/m2 carfilzomib administered once-weekly in combination with lenalidomide and dexamethasone (KRd 56 mg/m2) to 27 mg/m2 carfilzomib administered twice-weekly in combination with lenalidomide and dexamethasone (KRd 27 mg/m2) in subjects with relapsed or refractory multiple myeloma (RRMM) with 1 to 3 prior lines of therapy.

Detailed Description:

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Robert A Moss Oncology, Fountain Valley, California, United States

Rocky Mountain Cancer Centers Denver Midtown, Denver, Colorado, United States

Hartford HealthCare Cancer Institute at The Hospital of Central Connecticut, Plainville, Connecticut, United States

Baptist MD Anderson Cancer Center, Jacksonville, Florida, United States

Advocate Lutheran General Hospital, Park Ridge, Illinois, United States

New York Oncology Hematology, PC, Albany, New York, United States

Oncology Hematology Care Inc, Cincinnati, Ohio, United States

Texas Oncology-Denton, Denton, Texas, United States

US Oncology Research Investigational Products Center, Fort Worth, Texas, United States

Oncology Consultants PA, Houston, Texas, United States

Texas Oncology, San Antonio, Texas, United States

United States Oncology Regulatory Affairs Corporate Office, The Woodlands, Texas, United States

Universitaetsklinikum Salzburg, Salzburg, , Austria

University Multiprofile Hospital for Active Treatment Sveti Georgi EAD, Plovdiv, , Bulgaria

University Multiprofile Hospital for Active Treatment Sveti Ivan Rilski EAD, Sofia, , Bulgaria

Specialized Hospital for Active Treatment of Hematology Diseases EAD, Sofia, , Bulgaria

Fakultni nemocnice Brno, Brno, , Czechia

Fakultni nemocnice Hradec Kralove, Hradec Kralove, , Czechia

Fakultni nemocnice Olomouc, Olomouc, , Czechia

Vseobecna fakultni nemocnice v Praze, Praha 2, , Czechia

Helsingin Yliopistollinen Keskussairaala, Helsinki, , Finland

Oulun Yliopistollinen Sairaala, Oulu, , Finland

Turun Yliopistollinen Keskussairaala, Turku, , Finland

Centre Hospitalier Universitaire de Nantes, Nantes, , France

Centre Hospitalier Universitaire Archet 2, Nice cedex 3, , France

Hopital Saint Louis, Paris, , France

Hopital Pitie-Salpetriere, Paris, , France

Centre Hospitalier Lyon Sud, Pierre-Benite, , France

Centre Hospitalier Universitaire de Poitiers - Hopital la Miletrie, Poitiers Cedex, , France

Centre Hospitalier Universitaire de Rennes, Rennes, , France

Institut de Cancerologie Strasbourg, Strasbourg, , France

Institut Universitaire du Cancer Toulouse Oncopole, Toulouse cedex 9, , France

Centre Hospitalier Universitaire de Nancy - Hopital de Brabois, Vandoeuvre les Nancy Cedex, , France

Charité, Universitätsklinikum Berlin, Campus Benjamin Franklin, Berlin, , Germany

Universitätsklinikum Carl Gustav Carus der Technischen Universität Dresden, Dresden, , Germany

Universitatsklinikum Hamburg-Eppendorf, Hamburg, , Germany

Universitatsklinikum Koln, Köln, , Germany

Johannes Gutenberg Universitaet Mainz, Mainz, , Germany

University Hospital of Alexandroupolis, Alexandroupoli, , Greece

General Hospital Evangelismos, Athens, , Greece

Agios Savvas Anticancer Hospital, Athens, , Greece

251 General Airforce Hospital, Athens, , Greece

Alexandra Hospital, Athens, , Greece

Metropolitan Hospital, Athens, , Greece

General University Hospital of Patras Panagia i Voithia, Patra, , Greece

Theagenion Cancer Hospital of Thessaloniki, Thessaloniki, , Greece

General Hospital of Thessaloniki Georgios Papanikolaou, Thessaloniki, , Greece

Nagoya City University Hospital, Nagoya-shi, Aichi, Japan

Toyohashi Municipal Hospital, Toyohashi-shi, Aichi, Japan

Tesshokai Kameda General Hospital, Kamogawa-shi, Chiba, Japan

National Hospital Organization Kyushu Cancer Center, Fukuoka-shi, Fukuoka, Japan

Ogaki Municipal Hospital, Ogaki-shi, Gifu, Japan

National Hospital Organization Shibukawa Medical Center, Shibukawa-shi, Gunma, Japan

Japanese Red Cross Society Himeji Hospital, Himeji-shi, Hyogo, Japan

Hyogo College of Medicine Hospital, Nishinomiya-shi, Hyogo, Japan

Hitachi Ltd Hitachi General Hospital, Hitachi-shi, Ibaraki, Japan

University Hospital Kyoto Prefectural University of Medicine, Kyoto-shi, Kyoto, Japan

National Hospital Organization Sendai Medical Center, Sendai-shi, Miyagi, Japan

Niigata Cancer Center Hospital, Niigata-shi, Niigata, Japan

National Hospital Organization Okayama Medical Center, Okayama-shi, Okayama, Japan

Japanese Red Cross Osaka Hospital, Osaka-shi, Osaka, Japan

Kindai University Hospital, Osakasayama-shi, Osaka, Japan

Osaka University Hospital, Suita-shi, Osaka, Japan

Saitama Medical Center, Kawagoe-shi, Saitama, Japan

Tochigi Cancer Center, Utsunomiya-shi, Tochigi, Japan

Juntendo University Hospital, Bunkyo-ku, Tokyo, Japan

The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Koto-ku, Tokyo, Japan

Japanese Red Cross Medical Center, Shibuya-ku, Tokyo, Japan

Hospital of Lithuanian University of Health Sciences Kaunas Clinics Public Institution, Kaunas, , Lithuania

Vilnius University Hospital Santaros Clinic Public Institution, Vilnius, , Lithuania

VU Medisch Centrum, Amsterdam, , Netherlands

Gelre Ziekenhuizen, Apeldoorn, , Netherlands

Spaarne Gasthuis, Hoofddorp, , Netherlands

Fundeni Clinical Institute, Bucharest, , Romania

Institutul Clinic Fundeni, Bucharest, , Romania

Spitalul Clinic Coltea, Bucharest, , Romania

Spitalul Universitar de Urgenta Bucuresti, Bucharest, , Romania

Spitalul Clinic Colentina, Bucuresti, , Romania

Institutul Oncologic Prof Dr Ion Chiricuta, Cluj-Napoca, , Romania

Institutul Regional de Oncologie Iasi, Iasi, , Romania

Spitalul Clinic Dr Gavril Curteanu Oradea, Oradea, , Romania

Spitalul Clinic Judetean de Urgenta Sibiu, Sibiu, , Romania

Spitalul Clinic Municipal de Urgenta Timisoara, Timisoara, , Romania

Regional Clinical Hospital, Krasnoyarsk, , Russian Federation

Moscow State Budget Healthcare Institution City clinical Hospital 52 of Moscow Healthcare Department, Moscow, , Russian Federation

SBHI of Moscow city City clinical hospital na S P Botkin of Moscow city Healthcare department, Moscow, , Russian Federation

SBHI of Republic of Karelia Republic Hosiptal n a V A Baranov, Petrozavodsk, , Russian Federation

Federal centre of heart, blood and endocrinology Almazova, Saint Petersburg, , Russian Federation

State Budget Educational Institution of High Professional Skills Samara State Medical University, Samara, , Russian Federation

Univerzitna nemocnica Bratislava, Nemocnica sv Cyrila a Metoda, Bratislava, , Slovakia

Hospital Universitari Son Espases, Palma de Mallorca, Baleares, Spain

Hospital Clinico Universitario de Salamanca, Salamanca, Castilla León, Spain

Hospital Universitari Germans Trias i Pujol, Badalona, Cataluña, Spain

Hospital Clinic i Provincial de Barcelona, Barcelona, Cataluña, Spain

Hospital Universitario Quironsalud Madrid, Pozuelo de Alarcon, Madrid, Spain

Clinica Universidad de Navarra, Pamplona, Navarra, Spain

Falu Lasarett, Falun, , Sweden

Sahlgrenska Universitetssjukhuset, Goteborg, , Sweden

Hallands Sjukhus Halmstad, Halmstad, , Sweden

Sunderby Sjukhus, Lulea, , Sweden

Skanes Universitetssjukhus, Lund, , Sweden

Gazi Universitesi Saglik Arastirma ve Uygulama Merkezi Gazi Hastanesi, Ankara, , Turkey

Ankara Universitesi Tip Fakultesi Cebeci Arastirma ve Uygulama Hastanesi, Ankara, , Turkey

Istanbul Universitesi Istanbul Tip Fakultesi, Istanbul, , Turkey

Bagcilar Medipol Mega Universite Hastanesi, Istanbul, , Turkey

Istanbul Florence Nightingale Hastanesi, Istanbul, , Turkey

Dokuz Eylul Universitesi Arastirma Uygulama Hastanesi, Izmir, , Turkey

Erciyes Universitesi Tip Fakultesi Mehmet Kemal Dedeman Hematoloji-Onkoloji Hastanesi, Kayseri, , Turkey

Contact Details

Name: MD

Affiliation: Amgen

Role: STUDY_DIRECTOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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