Spots Global Cancer Trial Database for A Dose Escalation and Cohort Expansion Study of KB-0742 in Participants With Relapsed or Refractory Solid Tumors or Non-Hodgkin Lymphoma
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Trial Identification
Brief Title: A Dose Escalation and Cohort Expansion Study of KB-0742 in Participants With Relapsed or Refractory Solid Tumors or Non-Hodgkin Lymphoma
Official Title: Phase 1, First-in-human, Open-label Dose Escalation and Cohort Expansion Study of KB-0742 in Patients With Relapsed or Refractory Solid Tumors or Non-Hodgkin Lymphoma
Study ID: NCT04718675
Interventions
Study Description
Brief Summary: Part 1: Dose Escalation. The primary objective of Part 1 of this study is to evaluate the safety and tolerability of KB-0742 in participants with relapsed or refractory (R/R) solid tumors or non-Hodgkin lymphoma (NHL). Part 2: Cohort Expansion. The primary objective of Part 2 of this study is to further evaluate the safety and tolerability of KB-0742 in defined participant cohorts.
Detailed Description:
Eligibility
Minimum Age: 12 Years
Eligible Ages: CHILD, ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
City of Hope, Duarte, California, United States
MemorialCare - Orange Coast Medical Center, Fountain Valley, California, United States
City of Hope - Orange County Lennar Foundation Cancer Center, Irvine, California, United States
Precision NextGen Oncology, Los Angeles, California, United States
Norris Comprehensive Cancer Center, Los Angeles, California, United States
Cedars Sinai, Los Angeles, California, United States
University of California, Los Angeles (UCLA), Los Angeles, California, United States
Community Health Network Community Cancer Center South, Indianapolis, Indiana, United States
Community Health Network Community Cancer Center North, Indianapolis, Indiana, United States
Massachusetts General Hospital, Boston, Massachusetts, United States
Dana Farber Cancer Institute, Boston, Massachusetts, United States
University of Michigan Rogel Cancer Center, Ann Arbor, Michigan, United States
Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, United States
Washington University, Saint Louis, Missouri, United States
Cleveland Clinic - Taussig Cancer Center, Cleveland, Ohio, United States
Pennsylvania Cancer Specialists Research Institute - Gettysburg Cancer Center, Gettysburg, Pennsylvania, United States
Thomas Jefferson University, Philadelphia, Pennsylvania, United States
SCRI Tennessee Oncology, Nashville, Tennessee, United States
Oncology Consultants Texas Medical Center, Houston, Texas, United States
The University of Texas MD Anderson Cancer Center, Houston, Texas, United States
South Texas Accelerated Research Therapeutics, San Antonio, Texas, United States
Virginia Cancer Specialists, Fairfax, Virginia, United States
Hospital Clinic de Barcelona, Barcelona, , Spain
Hospital Clínico San Carlos, Madrid, , Spain
Hospital Universitario Quirónsalud Madrid, Madrid, , Spain
Sarah Cannon Research Institute London, London, , United Kingdom
Contact Details
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