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Brief Title: A Study of Avastin (Bevacizumab) Added to Interferon Alfa-2a (Roferon) Therapy in Patients With Metastatic Renal Cell Cancer With Nephrectomy
Official Title: A Randomised, Double-blind Study to Evaluate the Efficacy and Safety of Avastin Plus Roferon Compared With Placebo Plus Roferon on Overall Survival and Tumor Assessment in Nephrectomised Patients With Metastatic Clear Cell Renal Cell Carcinoma
Study ID: NCT00738530
Brief Summary: This 2-arm study will evaluate the efficacy and safety of Avastin versus placebo in combination with Roferon as first-line treatment in participants with metastatic renal cell cancer (clear cell type) who have had nephrectomy. The anticipated time of study treatment is 1-2 years, and the target sample size is greater than (\>)500 individuals.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
, Adelaide, , Australia
, Adelaide, , Australia
, Brisbane, , Australia
, Canberra, , Australia
, Frankston, , Australia
, Kurralta Park, , Australia
, Melbourne, , Australia
, Perth, , Australia
, Sydney, , Australia
, Sydney, , Australia
, Antwerpen, , Belgium
, Bruxelles, , Belgium
, Bruxelles, , Belgium
, Wilrijk, , Belgium
, Ceské Budejovice, , Czech Republic
, Chomutov, , Czech Republic
, Hradec Kralove, , Czech Republic
, Plzen, , Czech Republic
, Tampere, , Finland
, Turku, , Finland
, Angers, , France
, Bordeaux, , France
, Caen, , France
, Clermont Ferrand, , France
, Grenoble, , France
, Lille, , France
, Limoges, , France
, Lyon, , France
, Marseille, , France
, Nice, , France
, Poitiers, , France
, Saint Herblain, , France
, Strasbourg, , France
, Suresnes, , France
, Toulouse, , France
, Villejuif, , France
, Berlin, , Germany
, Darmstadt, , Germany
, Hamburg, , Germany
, Hannover, , Germany
, Mannheim, , Germany
, Marburg, , Germany
, München, , Germany
, Planegg, , Germany
, Budapest, , Hungary
, Szombathely, , Hungary
, Holon, , Israel
, Ramat-gan, , Israel
, Rehovot, , Israel
, Tel Aviv, , Israel
, Zerifin, , Israel
, Livorno, , Italy
, Milano, , Italy
, Milano, , Italy
, Modena, , Italy
, Napoli, , Italy
, Perugia, , Italy
, Roma, , Italy
, Rozzano, , Italy
, Torino, , Italy
, Amsterdam, , Netherlands
, Nijmegen, , Netherlands
, Oslo, , Norway
, Stavanger, , Norway
, Trondheim, , Norway
, Ålesund, , Norway
, Bydgoszcz, , Poland
, Krakow, , Poland
, Lodz, , Poland
, Olsztyn, , Poland
, Tarnow, , Poland
, Warszawa, , Poland
, Moscow, , Russian Federation
, Moscow, , Russian Federation
, Moscow, , Russian Federation
, Moscow, , Russian Federation
, Moscow, , Russian Federation
, Moscow, , Russian Federation
, Obninsk, , Russian Federation
, St Petersburg, , Russian Federation
, St Petersburg, , Russian Federation
, Singapore, , Singapore
, Singapore, , Singapore
, Barcelona, , Spain
, Barcelona, , Spain
, Barcelona, , Spain
, Granada, , Spain
, Madrid, , Spain
, Madrid, , Spain
, Málaga, , Spain
, Pontevedra, , Spain
, Santander, , Spain
, Valencia, , Spain
, Zaragoza, , Spain
, Basel, , Switzerland
, Bern, , Switzerland
, Geneve, , Switzerland
, Chang Gung, , Taiwan
, Kaohsiung, , Taiwan
, Taichung, , Taiwan
, Taipei, , Taiwan
, London, , United Kingdom
, London, , United Kingdom
, Manchester, , United Kingdom
Name: Clinical Trials
Affiliation: Hoffmann-La Roche
Role: STUDY_DIRECTOR